ID   A0A1H3EEG1_9EURY        Unreviewed;       244 AA.
AC   A0A1H3EEG1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE            EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN   ORFNames=SAMN05216564_101405 {ECO:0000313|EMBL:SDX77096.1};
OS   Halopenitus persicus.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Halorubraceae; Halopenitus.
OX   NCBI_TaxID=1048396 {ECO:0000313|EMBL:SDX77096.1, ECO:0000313|Proteomes:UP000199079};
RN   [1] {ECO:0000313|EMBL:SDX77096.1, ECO:0000313|Proteomes:UP000199079}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DC30,IBRC 10041,KCTC 4046 {ECO:0000313|Proteomes:UP000199079};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC         Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC         Evidence={ECO:0000256|ARBA:ARBA00001156};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC       biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005010}.
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DR   EMBL; FNPC01000001; SDX77096.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3EEG1; -.
DR   OrthoDB; 10510at2157; -.
DR   UniPathway; UPA00262; UER00222.
DR   Proteomes; UP000199079; Unassembled WGS sequence.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR028161; Met8-like.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006367; Sirohaem_synthase_N.
DR   NCBIfam; TIGR01470; cysG_Nterm; 1.
DR   PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   Pfam; PF13241; NAD_binding_7; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   REGION          206..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..244
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   244 AA;  26061 MW;  470DD546108F35E5 CRC64;
     MIPLVHDLSG ETVLVVGGGA VATRKARRFA AEASVIVVSP TFTERLRSTV DRTVGDETDD
     DETGTDDGRI ELVRQRVDAD DVATWIDRAE PALVVAATDD PTINAAAEAA ARERDALVNR
     TDVSGDRDPG SVVVPATVED GPVTIAITTG ATSPAVSRYL RERIETEFDG IGDLARLSGD
     VRTELIERGV EPDTRREAVR AVVRSPAVQK GLQTGESNPR QLADGIVERV RDHEDDPGDT
     SEGQ
//