ID A0A1H3F4Y8_9FIRM Unreviewed; 729 AA.
AC A0A1H3F4Y8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=PTS system maltose-specific IIA component, Glc family /PTS system maltose-specific IIB component, Glc family /PTS system maltose-specific IIC component, Glc family {ECO:0000313|EMBL:SDX86051.1};
GN ORFNames=SAMN02910414_00146 {ECO:0000313|EMBL:SDX86051.1};
OS Lachnobacterium bovis DSM 14045.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Lachnobacterium.
OX NCBI_TaxID=1122142 {ECO:0000313|EMBL:SDX86051.1, ECO:0000313|Proteomes:UP000183918};
RN [1] {ECO:0000313|EMBL:SDX86051.1, ECO:0000313|Proteomes:UP000183918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14045 {ECO:0000313|EMBL:SDX86051.1,
RC ECO:0000313|Proteomes:UP000183918};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FNPG01000004; SDX86051.1; -; Genomic_DNA.
DR RefSeq; WP_074715083.1; NZ_FNPG01000004.1.
DR AlphaFoldDB; A0A1H3F4Y8; -.
DR STRING; 1122142.SAMN02910414_00146; -.
DR OrthoDB; 9764327at2; -.
DR Proteomes; UP000183918; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00212; PTS_IIB_glc; 1.
DR Gene3D; 2.70.70.10; Glucose Permease (Domain IIA); 1.
DR Gene3D; 3.30.1360.60; Glucose permease domain IIB; 1.
DR InterPro; IPR011055; Dup_hybrid_motif.
DR InterPro; IPR036878; Glu_permease_IIB.
DR InterPro; IPR018113; PTrfase_EIIB_Cys.
DR InterPro; IPR001127; PTS_EIIA_1_perm.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013013; PTS_EIIC_1.
DR InterPro; IPR001996; PTS_IIB_1.
DR InterPro; IPR011300; PTS_IIBC.
DR NCBIfam; TIGR00826; EIIB_glc; 1.
DR NCBIfam; TIGR00830; PTBA; 1.
DR NCBIfam; TIGR02003; PTS-II-BC-unk1; 1.
DR PANTHER; PTHR30009; CYTOCHROME C-TYPE SYNTHESIS PROTEIN AND PTS TRANSMEMBRANE COMPONENT; 1.
DR PANTHER; PTHR30009:SF8; PTS SYSTEM, IIBC COMPONENT; 1.
DR Pfam; PF00358; PTS_EIIA_1; 1.
DR Pfam; PF00367; PTS_EIIB; 1.
DR Pfam; PF02378; PTS_EIIC; 1.
DR SUPFAM; SSF51261; Duplicated hybrid motif; 1.
DR SUPFAM; SSF55604; Glucose permease domain IIB; 1.
DR PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
DR PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
DR PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000183918};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 189..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..126
FT /note="PTS EIIA type-1"
FT /evidence="ECO:0000259|PROSITE:PS51093"
FT DOMAIN 177..626
FT /note="PTS EIIC type-1"
FT /evidence="ECO:0000259|PROSITE:PS51103"
FT DOMAIN 651..729
FT /note="PTS EIIB type-1"
FT /evidence="ECO:0000259|PROSITE:PS51098"
FT ACT_SITE 673
FT /note="Phosphocysteine intermediate; for EIIB activity"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00421"
SQ SEQUENCE 729 AA; 78477 MW; B9E052172FF65B73 CRC64;
MAKLDIVSPI KGNAIPLNEV PDDVFSQKIL GDGIAIEPVD GNIYSPVDGV IVTIPESLHA
YGIKTKEEVE VIVHFGLDTV SLKGEGFSPK VKVGDEVKKG DLLCEADVDL IKSKNLKLVS
PVIICGGAKL ETLTTSNGEV NVGDKILSIE PENSVEKNAN TDANNSTKKK KTKKASKFNF
EFLQKLGKAL MTVIAVMPAA GLMISLGNVI TMFAPASGAV HSIMTVTGST MADIGWAVIN
NLHLLFAAAI GGSWAKERAG GAFAAILSFC LINAITGVVF GVQTDMLTND SATVTTIFGK
SILVKDYFIN VLGKPALNMG VFVGIIAGFV GATAYNRFYN FRKLPDALSF FNGKRFVPLM
VIVYSSATAL FMSIVWPLVQ SGINSFGYWI ANSQKSSPIL APFIYGTLER LLLPFGLHHM
LTIPMNYTQF GGIYHQLTGS GAGKVVYGQD PLWLAWVTDL INLKNAGRTA EYQHLLTTVT
PARFKVGQMI GATGLLIGIA VAMYKHVDSD KKKRYRSMFV SVIAAVLLTG VTEPIEFMFM
FCALPLYLVY AVLQGCAFAL AGIIHLRLHS FGNIEFLTRV PMAVNAGLAF DILNFVICVV
AFFAIGFVVA NYMIPKFGFA TPGRLGNYEK DLLEPSQEKG TSNLEGVPVA NGQAAKIIEL
LGGRDNIDFV DACMTRLRVT VYDASKVASA EKWKEEGALG LVVKDNGIQA IYGPKADVIK
SDINDILTA
//
