ID A0A1H3F9E0_9ACTN Unreviewed; 681 AA.
AC A0A1H3F9E0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093};
GN ORFNames=SAMN05661080_01536 {ECO:0000313|EMBL:SDX87457.1};
OS Modestobacter sp. DSM 44400.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=1550230 {ECO:0000313|EMBL:SDX87457.1, ECO:0000313|Proteomes:UP000199500};
RN [1] {ECO:0000313|EMBL:SDX87457.1, ECO:0000313|Proteomes:UP000199500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44400 {ECO:0000313|EMBL:SDX87457.1,
RC ECO:0000313|Proteomes:UP000199500};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
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DR EMBL; FNOZ01000008; SDX87457.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3F9E0; -.
DR STRING; 1550230.SAMN05661080_01536; -.
DR OrthoDB; 9759185at2; -.
DR Proteomes; UP000199500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:SDX87457.1};
KW Cilium {ECO:0000313|EMBL:SDX87457.1};
KW Flagellum {ECO:0000313|EMBL:SDX87457.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000199500};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 31..47
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 54..73
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 93..120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 189..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 270..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT REGION 313..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 681 AA; 72570 MW; E537D17BA9FE40E9 CRC64;
MKKMTKVAVP IGVVSIILML VVPLPAAVLD LLLGFNITGS LLILLVSMQI RRPLEFSVFP
SLVLIATLMR LALNVSSTRL VLSDGYAGKV IEAFGHFVIG GSLIVGLVIF VILTIIQFVV
ITNGAGRVAE VGARFTLDAM PGKQMAIDAD LNAGLINEKQ ARKRRQEVTS EADFYGSMDG
ASKFVKGDAI ASIIVTLINL IGGFAIGVIQ RGLAPGEAVS TYSLLTVGDG LVSQIPALLL
STATGLIVTR SASEGDMGQD LLKQLGRNRM PVRIAGGAAL ALCLIPGLPK LPFLLVGGLF
LLLSFKMTET SDVDETEDDA APGAALEAQP DSPEAIAERM RVDPLELEVA FDLVELVDTA
RGGDLLDRVK ALRRKVAMDT GLVIPLVRTR DNLDLPASQY VIWLNGVPAA KGTSPAGTVL
AIGDHLDGLP GKPTREPVFG LAAKWVPAEL QRQAEMAGAT VVDRSSVITT HLAEVVRQNA
SALLGREDVR LLIEMVRRSH PVVVDELTPA LLTTGEVQRV LQALLDEDVS IRDLVRIFEA
LSLRAKTSTD LDGLVEAARS ALGSAISHPY VTPDERLHVI TLEPGFEQRL LESIRQGADG
QVLALDGHTV DVLVRGCTEL LDEAERMSLS PVLVCSPQVR APLSRLVRQV LPRLSVISYS
EVSRTAQIES LGVVSGAVAI R
//
