ID A0A1H3GP95_9EURY Unreviewed; 931 AA.
AC A0A1H3GP95;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=SAMN04487946_105261 {ECO:0000313|EMBL:SDY04448.1};
OS Halobellus clavatus.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Halobellus.
OX NCBI_TaxID=660517 {ECO:0000313|EMBL:SDY04448.1, ECO:0000313|Proteomes:UP000199170};
RN [1] {ECO:0000313|Proteomes:UP000199170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10118 {ECO:0000313|Proteomes:UP000199170};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; FNPB01000005; SDY04448.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3GP95; -.
DR STRING; 660517.SAMN04487946_105261; -.
DR OrthoDB; 45637at2157; -.
DR Proteomes; UP000199170; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR014808; DNA_replication_fac_Dna2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF08696; Dna2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SDY04448.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SDY04448.1};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000199170}.
FT DOMAIN 60..231
FT /note="DNA replication factor Dna2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08696"
FT DOMAIN 535..624
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 632..699
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 730..913
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 28..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 100526 MW; BD654437C1273809 CRC64;
MKLRGRIVEV NDEREVETSY GTRSLAEVTI RPNPGNGRAS ADGGPDVDGE SHADVAGGAA
QLTLWGKWTH TVEHAEPGME LLATDLETDE YRGEMTYATT GDSHVVLEPG FLVDVTDVRS
WVQCPRMYYL NKLSGIPLNY PVVKGTIVHE VFGDLLRDRD LAESIDERVG EAGLELGLLG
REAAEVRDEV RRNAAAIEGW LSQGTLTEED AWRSEYTLIS PTYGIKGRAD ALRRGMPVEL
KTGKNTKREP RFHDKIQAAA YALILDERGV AADTGTLLYT KNTALERTEE TGDLSPAKEF
SIGDGLLDFV VRTRNEIAAM EFDSSVPTGY EADARCEYCF EQDTCMVVSG RLDQESKAGQ
IGSPVPDAER AYFDRFYQAI EAERRAVHAE YRKLWEQSAE ARAADDRALI DLEPAGRTEL
DDGRWELRAR KPAEAVSKLR EGDVALASDG DPVAGHAELC RIVAVGDDVV VRADEPLSVR
RLDVYPSEIG VDRMLTALHD FVLKGDPDTK DVLFGRRDPV FADRAASPGT YVDNNAAQDE
AVRLAVDADD IALIHGPPGT GKTHTIARIV RTLVESGERV LLSAFTNRAV DNALEAVREA
GVADVVRVGT ENGVREDMLD VRLERGGEPN ERAAALRDAP VVAATTATCG SRVMREQSFD
VALVDEASQL TEPSTLAATN LADRFVLVGD HQQLPPVVQA GPTPGGDDAG ASAGDDDAGA
GAGDGDANAL STSLFERLID AHPDASVLLD RQYRMAQRIQ AFSSQEFYDG ALRPASGSVA
AQGLADLGVD EGALPPALRD PVAFVDPQGE RVGNTNPAEA DRVADLVDAY VDAGVDPDDI
GVIAPFRAQV AEIARRTDVS VDTVDRFQGS AKEVILVSFV ASGTLDGPLF EDHRRMNVAL
TRAKKALTLV GDADALGSDP FYARLLDWAQ R
//
