ID A0A1H3GRM9_9ACTN Unreviewed; 1014 AA.
AC A0A1H3GRM9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Adenylate and Guanylate cyclase catalytic domain-containing protein {ECO:0000313|EMBL:SDY05931.1};
GN ORFNames=SAMN05444365_101533 {ECO:0000313|EMBL:SDY05931.1};
OS Micromonospora pattaloongensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=405436 {ECO:0000313|EMBL:SDY05931.1, ECO:0000313|Proteomes:UP000242415};
RN [1] {ECO:0000313|Proteomes:UP000242415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45245 {ECO:0000313|Proteomes:UP000242415};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNPH01000001; SDY05931.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3GRM9; -.
DR STRING; 405436.SAMN05444365_101533; -.
DR OrthoDB; 33864at2; -.
DR Proteomes; UP000242415; Unassembled WGS sequence.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000242415}.
FT DOMAIN 13..126
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 427..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..1001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1014 AA; 108177 MW; B2E893FA96FD58A5 CRC64;
MSARTHLPSG LVTFLFTDIE GSTRLARMLG AGYLPVLSEH RRLLRRTLAT SDGAELFTEG
DSFFVAFADA GAAMAACASA QRALTEHEWP TPDSTPRVRM GLHTGHAEPV GGEYASPEVH
RAARIAAAAH GGQVLCSAAT ARHAAPLPAD ASLLDLGLHR LRGFDDRERL FQLVAPGLER
QFPRPRTVDA ATHNLPNQAT AFVGREAERA ELDALVRGHR LVTVVGAGGA GKTRLAVELA
ARTVGVYPDG VWFVDIATVT DPGLVAFAIA AVLGLRPEPG RPIVDTLVEH ATSRRMLLLL
DTCDAHLPAV ADVTARLLTG GSGVHVLATS REPFGLPGEV VWRIPPLSVE PPPGGGPSDA
VALLLERTSA ARGGRFPSPA ESVDLQRVVA RLDGLPLAIE LAAARLRVLS AGQLAERLDD
VLGTLDAGRS EDAGRTEDAG RSEDAGRGDD AARGDDAGRP GPARDDRARV RPPGWVSAAR
GGDGRTAMRE TSADARRRAL AAGVLVPQQR TPRSVTQRHI TMQATVSWSY RTLGPRAARL
LRWLSVFSGP VDLPTVEWLL EEDALDPLAV LVDKSMIQAE PHASGSTYRM LDPIRGYAAR
RLVEAGEERA ARDRHVAWAL HALRQAHLGR DGQPVTLSLY ALDPLADEVR AGLRWSATGG
SARRGLQLSS GLDQWWRERG IGREGRLWLF RLYGRIAETG EPIPEAELAA AYHMHSLHAG
ADGEFAEELR FSQRAEAAAR QAGDAALLAR VLGGRGATLI DMGQLVEAER VCREVIDGAN
ADGVAGDGLF AVYSLAELLW RRGALDEAAE LLGAARPVEA TRPVERGRRT VDMLLGMVAL
ARRDLVAAHD HLVVALRSRM TYGFHRRACE TLNAMAVRCA LGGDPVTAAR LFGAAQATRT
VLRGTPGMFG AYWADEQAAV RSAIGDPAFD AAYAEGAELS LEEAAVVALA VEHPDLTIGS
RRFAGGEMGA REATPRHPAG KREASAVRDV APRRDPSRRD SAATTAPRSA RPRP
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