ID A0A1H3GXE0_9ACTN Unreviewed; 874 AA.
AC A0A1H3GXE0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:SDY07986.1};
GN ORFNames=SAMN05661080_02241 {ECO:0000313|EMBL:SDY07986.1};
OS Modestobacter sp. DSM 44400.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=1550230 {ECO:0000313|EMBL:SDY07986.1, ECO:0000313|Proteomes:UP000199500};
RN [1] {ECO:0000313|EMBL:SDY07986.1, ECO:0000313|Proteomes:UP000199500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44400 {ECO:0000313|EMBL:SDY07986.1,
RC ECO:0000313|Proteomes:UP000199500};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FNOZ01000014; SDY07986.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3GXE0; -.
DR STRING; 1550230.SAMN05661080_02241; -.
DR Proteomes; UP000199500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199500};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 534..728
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 840..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 89321 MW; E363AC3E09BFEA17 CRC64;
MTTDRWSWVD LRLVPPAVTV WLLTLVARTW APATLGVLAV GCAVLATVLL VRGRRPGLAR
WPARAAVAVA CLAAATAVSA TAAARAADRA GSPLAQLAAE EAIAPVLVRV DDDPRPLSGM
GKPRVLIAAT VEEAAGLPVR GGAVLVFGPA AEWSGLLPGQ QVRLRAAVRP AEPGDDVVAV
LSARSPPVGA GGPGRVQQVA GVLRTGLADS AARALDPRPA GLLPGLVVGD TGAMDPALTS
EFHRAGLSHL TAVSGANVAI AVALVLWPLR RRAVDRRVQA AVGLLALVAF VVLARPGASV
LRAGAMGAVT LVALASGRSR AAVPALSAAV AVLLLLDPTL ARDGGFVLSV AATVAIVLLA
PPWALALRRR GVPRLPAEAI AVSAAAGLVT APLVAAFSGV VSLVSLPANL LAAPAVAPAT
VLGLGAAVMS PILPGAADVL SWLAGWPVRW LVVVAERAAA VPDGAAGWPA GLRGAVLLAV
LLAGGAVVLL RWPRLRPLFL AALLGVVLLG WPLRQAARGW PPADTVLVAC DVGQGDALVL
PTAPGEGVLV DAGPDATGVD SCLTRLGVDR LPLVLLSHLD ADHVAGLAGA LTGRKVGVVA
TGTLAPTDDR VGSLERLVVR SGGRHVVLEP GEIRTVGDAR FEVLAPRAAA ATAGAEPNDL
SMVVRASQRG VRVLLTGDLG AEAEQRLVSA GVDLQADVLK VPHHGSADAD PGFLAASGAQ
VAVVSVGVDN TYGHPTDRLL DWLAEDRMRV YRTDRDGDVA VVGRAGDWGV AVRGPDTVAR
ATAGGLPVAG VPVDLRRAAR CAATGRSVPR DTMGPWQQHP RHRRRTCGWW WARRSCCVPA
RSPPSGRRSA TPIPTPRSTS SSPAACRWAP WPRR
//
