ID   A0A1H3H3N6_9PSEU        Unreviewed;       756 AA.
AC   A0A1H3H3N6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Zn-dependent metalloprotease {ECO:0000313|EMBL:SDY09364.1};
GN   ORFNames=SAMN05421504_104481 {ECO:0000313|EMBL:SDY09364.1};
OS   Amycolatopsis xylanica.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=589385 {ECO:0000313|EMBL:SDY09364.1, ECO:0000313|Proteomes:UP000199515};
RN   [1] {ECO:0000313|EMBL:SDY09364.1, ECO:0000313|Proteomes:UP000199515}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CPCC 202699 {ECO:0000313|EMBL:SDY09364.1,
RC   ECO:0000313|Proteomes:UP000199515};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNON01000004; SDY09364.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3H3N6; -.
DR   STRING; 589385.SAMN05421504_104481; -.
DR   OrthoDB; 345880at2; -.
DR   Proteomes; UP000199515; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd09597; M4_TLP; 1.
DR   Gene3D; 3.10.170.10; -; 1.
DR   Gene3D; 3.10.450.490; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR011096; FTP_domain.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   InterPro; IPR001570; Peptidase_M4_C_domain.
DR   InterPro; IPR013856; Peptidase_M4_domain.
DR   InterPro; IPR006311; TAT_signal.
DR   PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR   PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR   Pfam; PF07504; FTP; 1.
DR   Pfam; PF05345; He_PIG; 1.
DR   Pfam; PF01447; Peptidase_M4; 1.
DR   Pfam; PF02868; Peptidase_M4_C; 1.
DR   SUPFAM; SSF49313; Cadherin-like; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000313|EMBL:SDY09364.1};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SDY09364.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199515};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..756
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011501832"
FT   DOMAIN          64..106
FT                   /note="FTP"
FT                   /evidence="ECO:0000259|Pfam:PF07504"
FT   DOMAIN          198..333
FT                   /note="Peptidase M4"
FT                   /evidence="ECO:0000259|Pfam:PF01447"
FT   DOMAIN          346..505
FT                   /note="Peptidase M4 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02868"
SQ   SEQUENCE   756 AA;  77185 MW;  559664EA9AB63535 CRC64;
     MKLRRPGVLA AAGVLAAAIA TTSAAQAAQP PAAAQSAEAM AVSAAESLVA AKPAALHASN
     DDVFVQRNVI SSTNGLKYIP YERTYKGLPV VGGDFVVATN STGQVVGTSV AQDVAINLPT
     TTPKLSAAQA EAIARKQLST VDSAAAPQLV TFALGSSPAL AWKSTVVGKD AEGASKLDVV
     VDAATGAVLH TQEHVMNGDG NSAYNGPAVH LDTTHSGSTY SLKDPAITNT SCQDAANNTT
     FSGPDDAWGN GNATSRETGC VDALFAAQTE NKMLSQWLGR NSFDGNGGGW PVRVGLNDLN
     AYYDGSQIQI GHNQSNQWIG SLDVVAHEHG HGIDDHTPGG ISGAGTQEFV ADVFGTSTEW
     FANESSPYDT PDFLIGETIN LVGSGPIRNM YNPSALGHKN CYDSQIPNTE VHAAAGPGNH
     WFYLLAEGTN PTNGQPTSTT CNNTSITGLG VQSALKIFYN AMLIKTSGAS YLKYRTWTLT
     AAKNLFPGSC TEFNTVKAAW DAVSVPAQSG DPTCSATGTV TVSNPGNQST VTGSAVNLPL
     SASGGTAPYS WTATGLPAGL SINASTGTIS GTATTAGTSN VTVTAKDAAN KTGSASFTWT
     VGTSNPTCSG QKLTNGGFES GSTGWTASSG VIGANGPDQP ARGGTQNAWL DGYGSSHTDT
     LAQSVAIPAG CHATLTFYLH IDTNETGSTV YDKLTVANGS TTLATYSNVN AAAGYVLKTI
     DVSSAAGQTL SLKFTGVEDA SLQTSFVIDD AAVTLS
//