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Database: UniProt
Entry: A0A1H3HNW9_9FIRM
LinkDB: A0A1H3HNW9_9FIRM
Original site: A0A1H3HNW9_9FIRM 
ID   A0A1H3HNW9_9FIRM        Unreviewed;       366 AA.
AC   A0A1H3HNW9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   ORFNames=SAMN02910414_00929 {ECO:0000313|EMBL:SDY17191.1};
OS   Lachnobacterium bovis DSM 14045.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Lachnobacterium.
OX   NCBI_TaxID=1122142 {ECO:0000313|EMBL:SDY17191.1, ECO:0000313|Proteomes:UP000183918};
RN   [1] {ECO:0000313|EMBL:SDY17191.1, ECO:0000313|Proteomes:UP000183918}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14045 {ECO:0000313|EMBL:SDY17191.1,
RC   ECO:0000313|Proteomes:UP000183918};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; FNPG01000009; SDY17191.1; -; Genomic_DNA.
DR   RefSeq; WP_074716558.1; NZ_FNPG01000009.1.
DR   AlphaFoldDB; A0A1H3HNW9; -.
DR   STRING; 1122142.SAMN02910414_00929; -.
DR   eggNOG; COG1420; Bacteria.
DR   OrthoDB; 9783139at2; -.
DR   Proteomes; UP000183918; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000183918};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          108..331
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   366 AA;  41162 MW;  FA45307274543CF9 CRC64;
     MMKDDAEQLD ERKVKILDAI IRNYLATGEP VGSRTISKYT DLNLSSATIR NEMSDLEDLG
     YILQPHTSAG RIPSDKGYRF YVDHLIQEKD KEVTDMKEFV IEKTQKMEQV LKQVAKLLAN
     NTNYATMITA AHKSDNKVKF IQLSCVDERQ ILAVVVLNSN VVRNRIIDVD EKVDNESLLK
     LNILLNTALN GLSIEEINLG VISKIKEKAG NHSSIVNDVL DTLSKSFEED DNLEIYTSGA
     TNILKYPELS DAEKVTHLLE TFEDKEELVN LVTDTTENRE ETGIQVYIGN EAPIQTMKDC
     SVVTATYDLG DGVKGTVGII GPKRMDYENV MHNLKSLKKQ LEGMFNKNVI TDKSMKNDSN
     DSFDNN
//
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