ID   A0A1H3ICV9_9ACTN        Unreviewed;       587 AA.
AC   A0A1H3ICV9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   ORFNames=SAMN05661080_02843 {ECO:0000313|EMBL:SDY25285.1};
OS   Modestobacter sp. DSM 44400.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Modestobacter.
OX   NCBI_TaxID=1550230 {ECO:0000313|EMBL:SDY25285.1, ECO:0000313|Proteomes:UP000199500};
RN   [1] {ECO:0000313|EMBL:SDY25285.1, ECO:0000313|Proteomes:UP000199500}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44400 {ECO:0000313|EMBL:SDY25285.1,
RC   ECO:0000313|Proteomes:UP000199500};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR   EMBL; FNOZ01000021; SDY25285.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3ICV9; -.
DR   STRING; 1550230.SAMN05661080_02843; -.
DR   OrthoDB; 9761056at2; -.
DR   Proteomes; UP000199500; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199500};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        41..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        71..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        113..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        138..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        167..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        206..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        229..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        253..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        346..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        402..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        441..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        465..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        558..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   REGION          303..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  59938 MW;  48125467E99251B1 CRC64;
     MFEQVLDPVG GSLGLSALCA AIPLVTLFVL LGVLRMKAWQ AGLISLVVAI LVAVIFFDMP
     VGQSLLGATE GAAFGFFPIM WIVINAIWVY NLTVETGHFD VLRRSFEKVS PDLRVQAIII
     AFCFGALLEA LAGFGTPVAI TVVMLMTLGF APLKAAALAL IANTAPVAFG ALASPIVTLA
     TVTSGASDDS RLTVETIGAM VGRQTPILAV VVPLILVFVA DGKRGLREAW LPALTAGLSF
     AVAQFIASNY ISVPLTDIVA SLVAAGAVVL VTRVSKPART GALQAGVGAG AAGAAVGATA
     GTELGDRPGG QRSIDADAPS AGAGRTTGGG RAAAVVDSRN DVIKAYAPYL IIIVIFSIAN
     IAAVKAFLGK APFAYKFAWP GLHVFAPGAT EELSTGTFNF NWLGAAGTLL IISGIITALV
     LKVPPARALA AYGRTYAELK WAILTVMAVL ALAYVMNLSG QTASLGAYLA GAGAFFAFLA
     PVLGWIGVGV TGSDTSANAL FGALQVQTAA RAGLDPLLLA AANSSGGVLG KMISPQNLAI
     AAAAVGMAGK EGELFRKVFG WSLVLLLFMC VIVVLQSTPV LGWMIPG
//