ID   A0A1H3IEY3_9FIRM        Unreviewed;       513 AA.
AC   A0A1H3IEY3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Alanine or glycine:cation symporter, AGCS family {ECO:0000313|EMBL:SDY26162.1};
GN   ORFNames=SAMN02910264_01835 {ECO:0000313|EMBL:SDY26162.1};
OS   Ruminococcaceae bacterium YAD3003.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX   NCBI_TaxID=1520816 {ECO:0000313|EMBL:SDY26162.1, ECO:0000313|Proteomes:UP000199204};
RN   [1] {ECO:0000313|EMBL:SDY26162.1, ECO:0000313|Proteomes:UP000199204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YAD3003 {ECO:0000313|EMBL:SDY26162.1,
RC   ECO:0000313|Proteomes:UP000199204};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
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DR   EMBL; FNPA01000011; SDY26162.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3IEY3; -.
DR   STRING; 1520816.SAMN02910264_01835; -.
DR   OrthoDB; 9804874at2; -.
DR   Proteomes; UP000199204; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
DR   PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199204};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        163..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        205..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        244..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        338..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        390..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        429..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        453..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   513 AA;  55318 MW;  4F063BD58122A951 CRC64;
     MDAFIEKITE INDLINTFVW VKIGLFLLIG TGILMTFVTK FFQITHVGHW WKKTGGGVFD
     KKSHNKKEAG SVSQFQALCT ALAATIGTGN IAGVSAAICI GGPGAVFWMW VAAFFGMMTN
     YSENVLGIFY RRKNREGEWS GGAMYYLQDG LGNYKGCKYI GKILAVLFAI FAALASFGIG
     NMGQINKITL NLESAFFTEK VREVAIFGGT VRVVPLAIGM FLAVCAGVII IGGLKWIAAV
     AEKVVPFMAI AYILGALALV AINFAALPSA FAAIFKFAFG IKAVAGAAAG IAIKQVITQG
     CKRGVFSNEA GLGSSVMVHS NSDVKEPVKQ GMWGIFEVFA DTFIVCTMTA LVVLTSGYID
     LETGLVREGV EDATLVAKSF SNVFGIGGEW FIAIAILLFA FTTVLGWSHY GSKAIEYLWG
     TIAAKVYKVI FVAIIVFGAL MTSSLAWDIS DTFNGFMMIP NLIGVVSLCP LVKKITDNYV
     ARRIKNKTDV EPMLSYDENI QKEHAELVKQ GAE
//