ID A0A1H3IFC7_9FIRM Unreviewed; 494 AA.
AC A0A1H3IFC7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN02910264_01828 {ECO:0000313|EMBL:SDY25949.1};
OS Ruminococcaceae bacterium YAD3003.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX NCBI_TaxID=1520816 {ECO:0000313|EMBL:SDY25949.1, ECO:0000313|Proteomes:UP000199204};
RN [1] {ECO:0000313|EMBL:SDY25949.1, ECO:0000313|Proteomes:UP000199204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YAD3003 {ECO:0000313|EMBL:SDY25949.1,
RC ECO:0000313|Proteomes:UP000199204};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FNPA01000011; SDY25949.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3IFC7; -.
DR STRING; 1520816.SAMN02910264_01828; -.
DR OrthoDB; 138378at2; -.
DR Proteomes; UP000199204; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SDY25949.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000199204};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..262
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 386..491
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 494 AA; 56139 MW; 610FCB58347620DC CRC64;
MAFKSRFFAN MKISRKLVAV FLATSLIAMG VNLFIYINLN MALEKINSVF SSNISLNELS
DNLNQIHSGL TGYLETKGTD DLELYYSSTQ TMEELMKDLN STVTNNSVKL SERDIRNMLE
TYLKTADEAI QAKRGRNIDE YTAKYNECTK IRDYLNTYIY SVNNEQFKTN SNNYNALVNS
LRYTEIMSLL IFAVASVMNV LLIVILTNTI TRPLTRLSAK ADEISQGSPE NVEPLQVYSD
DEVGKVTKAF NEMLASIKDY IARIRTQLIT QSEMKEKNLL METHLKDAQL KYLQSQINPH
FLFNTLNAGA QLAMMEGADR TVEYIRNMAD FFRYNVKKNS ESVKLSEEIE LVDSYIYILN
VRFAGDILFE KEIDESLLGV MVPSMIIQPL VENSIKYGIK DVEPGEGKIT LSVYREGDNC
CIRVSDNGIG TDEDIIEKIM SNEKKPSETR GVGITNVMER LDLHYNNREV FEIKSKKNEG
TQVTIKIPLE AGNV
//
