ID   A0A1H3J5A4_9FIRM        Unreviewed;       302 AA.
AC   A0A1H3J5A4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=TIR domain-containing protein {ECO:0000313|EMBL:SDY35121.1};
GN   ORFNames=SAMN02910264_02035 {ECO:0000313|EMBL:SDY35121.1};
OS   Ruminococcaceae bacterium YAD3003.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX   NCBI_TaxID=1520816 {ECO:0000313|EMBL:SDY35121.1, ECO:0000313|Proteomes:UP000199204};
RN   [1] {ECO:0000313|EMBL:SDY35121.1, ECO:0000313|Proteomes:UP000199204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YAD3003 {ECO:0000313|EMBL:SDY35121.1,
RC   ECO:0000313|Proteomes:UP000199204};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNPA01000013; SDY35121.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3J5A4; -.
DR   STRING; 1520816.SAMN02910264_02035; -.
DR   OrthoDB; 2048536at2; -.
DR   Proteomes; UP000199204; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199204};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        176..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..115
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
SQ   SEQUENCE   302 AA;  34480 MW;  51BE5A953A9DDB51 CRC64;
     MEEKVKLFFV YCSECKQHVE EIRKELESRA EVLRLRDISE DTPENTPKNA WHKNALKMIE
     QADVIVYVVS EHTAENENVE WELRQSVEKQ KQIICLKLSS EYEINKSFYY FDSFTKENKC
     RGKVARNQEA LCSYIDDLNS AKRMEKIDNT NLLELYKSFS ATAESLLERR QTVNSFYTSA
     NAALITLGAT VIALSEGQNL VPKMLILIAV SIPGLILNRS WGQLLDSYQI NNSAKISVLS
     NLEKTLGASL YDEEWAEMKG KGYKSFSKIE RNVPRAFFIL FLLVDVIAAI FALVSLLSGL
     FV
//