ID A0A1H3KDL1_9ACTN Unreviewed; 593 AA.
AC A0A1H3KDL1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Ribonuclease Y {ECO:0000256|HAMAP-Rule:MF_00335};
DE Short=RNase Y {ECO:0000256|HAMAP-Rule:MF_00335};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00335};
GN Name=rny {ECO:0000256|HAMAP-Rule:MF_00335};
GN ORFNames=SAMN05444365_102459 {ECO:0000313|EMBL:SDY50250.1};
OS Micromonospora pattaloongensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=405436 {ECO:0000313|EMBL:SDY50250.1, ECO:0000313|Proteomes:UP000242415};
RN [1] {ECO:0000313|Proteomes:UP000242415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45245 {ECO:0000313|Proteomes:UP000242415};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC {ECO:0000256|HAMAP-Rule:MF_00335}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00335};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00335}.
CC -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000256|HAMAP-
CC Rule:MF_00335}.
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DR EMBL; FNPH01000002; SDY50250.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3KDL1; -.
DR STRING; 405436.SAMN05444365_102459; -.
DR OrthoDB; 9803205at2; -.
DR Proteomes; UP000242415; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00077; HDc; 1.
DR CDD; cd22431; KH-I_RNaseY; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR HAMAP; MF_00335; RNase_Y; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR017705; Ribonuclease_Y.
DR InterPro; IPR022711; RNase_Y_N.
DR NCBIfam; TIGR00277; HDIG; 1.
DR NCBIfam; TIGR03319; RNase_Y; 1.
DR PANTHER; PTHR12826; RIBONUCLEASE Y; 1.
DR PANTHER; PTHR12826:SF15; RIBONUCLEASE Y; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF12072; RNase_Y_N; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00335};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00335};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00335};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_00335};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000242415};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00335}; Transmembrane {ECO:0000256|HAMAP-Rule:MF_00335};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00335}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00335"
FT DOMAIN 409..502
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT COILED 53..119
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 147..226
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 593 AA; 64696 MW; A647ACBFC27C7F0D CRC64;
MTGLEWALIA AVVGLAVLVL VALALGARML RRIGVVRTAA DVVEEDPAFV AAKDRQEQSL
AALRTAADEA SSAVEQAKAA AAAARTDAAA AKAEASAARA EARRVLDAAR AEADTVLERA
HRQAEADAEQ VRTAARRSGE REIALLSTTV KEQAAEIERR AQRMDERERQ HSEEVERLAA
RERRLSAAAA TLTERENALA ARETALVEAE EQHRRELERI AGLTADAARA ELVESIEGQA
KREAALLVRD IEADARGTAE QRARNIVVDA IQRVASEQTA ESVVSVLHLP GDEMKGRIIG
REGRNIRAFE SVTGVNLIID DTPEAVLLSC FDPVRREIGR LTLEKLVLDG RIHPHRIEEV
FETAKHEVER LCHRAAEDAL VDVGITEIHP ELVTLLGRLR YRTSYGQNVL KHLVETAHIA
GVMAAELRLD IPTIKRCAFL HDIGKALTHE VEGSHALIGA DLARKYGESE DVVHAIEAHH
NEVAPQTIEA VLTQASDACS GGRPGARRES LEAYVKRLER IEEIAGGKSG VEKVFAMQAG
REIRVMVKPE DVDDIGAAVL ARDVAKQIEE ELTYPGQIRV TVVRESRVTE IAR
//
