GenomeNet

Database: UniProt
Entry: A0A1H3L1W7_9ACTN
LinkDB: A0A1H3L1W7_9ACTN
Original site: A0A1H3L1W7_9ACTN 
ID   A0A1H3L1W7_9ACTN        Unreviewed;       312 AA.
AC   A0A1H3L1W7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=SAMN05661080_03924 {ECO:0000313|EMBL:SDY57885.1};
OS   Modestobacter sp. DSM 44400.
OC   Bacteria; Actinobacteria; Geodermatophilales; Geodermatophilaceae;
OC   Modestobacter.
OX   NCBI_TaxID=1550230 {ECO:0000313|EMBL:SDY57885.1, ECO:0000313|Proteomes:UP000199500};
RN   [1] {ECO:0000313|EMBL:SDY57885.1, ECO:0000313|Proteomes:UP000199500}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44400 {ECO:0000313|EMBL:SDY57885.1,
RC   ECO:0000313|Proteomes:UP000199500};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; FNOZ01000040; SDY57885.1; -; Genomic_DNA.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000199500; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199500};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199500}.
FT   DOMAIN        8    186       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      200    277       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        179    179       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   312 AA;  32228 MW;  73190E5377A7FD60 CRC64;
     MPGTAPTRFA FLGPEGTFAE AALGTLAAPS EGASRPEPSV AAALAAVRAG ECEAALVPLE
     NSVEGSVPAT MDGLVNGEPL VITREVFLAV AFVLAVRPGT TLADVRTVAS HPHALAQCRS
     RVAALLPGAD VVPAASTADA ARRVAAGEWD AAVCASIAAN RYRLTALEAD LADHAGAVTR
     FVLVARPGPL PSPTGADKTT ITAVVPDRTG ALLDLLAEFA VRGISLTRIE SRPTRERLGV
     YSFSIDCEGH VRDRRVGDAL AALHRLCAEV RFLGSYPRAD DQPGKPVQDR VGDAAFGDAD
     AWLARVRTGS AG
//
DBGET integrated database retrieval system