ID A0A1H3LCW7_9EURY Unreviewed; 715 AA.
AC A0A1H3LCW7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SAMN05216564_10715 {ECO:0000313|EMBL:SDY61715.1};
OS Halopenitus persicus.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halopenitus.
OX NCBI_TaxID=1048396 {ECO:0000313|EMBL:SDY61715.1, ECO:0000313|Proteomes:UP000199079};
RN [1] {ECO:0000313|EMBL:SDY61715.1, ECO:0000313|Proteomes:UP000199079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DC30,IBRC 10041,KCTC 4046 {ECO:0000313|Proteomes:UP000199079};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; FNPC01000007; SDY61715.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3LCW7; -.
DR OrthoDB; 8639at2157; -.
DR Proteomes; UP000199079; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR CDD; cd05531; POLBc_B2; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT DOMAIN 293..692
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 715 AA; 80231 MW; 57CBCE441627F0CE CRC64;
MSFTIDFLDD GRILEWEATA DGAIATERHD YTPRFHVAPR DPASDLDLTT LQSVYDQHPD
VVATELVARR PGFRRDEEAV LAVDVAHIDR VIPLARQARQ LSAYPVGDLA CFNVDFSREF
RYCLETGADP TPASELSTLR LSVPVTETSN NVYGELAVAG DTVTGSPTDI LTAVQGALEA
HDPDILVCST SEIIPTLYDM ATTTDVDDFS LSRWPGVDYQ QLASRSTYSS YGRVGHSPAR
YNVPGRAIID ESNTFFYGET NLDGVLDLVS RSKKPVQELA WASIGNVLTA IQIREAHDRG
VLVPRNSWRH EFFKPMGTLH DADRGGFIFA PEVGLHENVH ELDFSSLYPN IICTRNVSPD
VIRCDCHRDR DDVPGLGYSI CDDNGYLVDV LQPIIDARDE IKADIRREKD RDDPDEERLA
ELEGRSGALK WILVACFGYQ GFNNAKFGRI ECHEAINAFA REILLTAKQR LEAGGWRVVH
GIVDSIWVTP DPDVDDSDRE DLETLATEIT ERVEIRLEHE SHYDWVAFVP QRKSDAGALT
KYFGKVAGDD EFKIRGIEAR QRSTPVFIED VQRDCLERLD ATQSPDAVLD CLQDAIKRLH
AGTVPVKQLV ERNRVSKPLE GYTQNTQNVA ALKRVREQDL AVHPGQDIEY VVVDDEKTSR
ERVALAHEEI ESYDASYYET QLVRAIESLL SPLGWDRTII QQELSGTREP ELTDF
//
