ID A0A1H3M3M0_9ACTN Unreviewed; 105 AA.
AC A0A1H3M3M0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Nickel/cobalt efflux system {ECO:0000256|RuleBase:RU362101};
GN ORFNames=SAMN05661080_04372 {ECO:0000313|EMBL:SDY71291.1};
OS Modestobacter sp. DSM 44400.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=1550230 {ECO:0000313|EMBL:SDY71291.1, ECO:0000313|Proteomes:UP000199500};
RN [1] {ECO:0000313|EMBL:SDY71291.1, ECO:0000313|Proteomes:UP000199500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44400 {ECO:0000313|EMBL:SDY71291.1,
RC ECO:0000313|Proteomes:UP000199500};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362101};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362101}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family.
CC {ECO:0000256|ARBA:ARBA00010892, ECO:0000256|RuleBase:RU362101}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362101}.
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DR EMBL; FNOZ01000054; SDY71291.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3M3M0; -.
DR STRING; 1550230.SAMN05661080_04372; -.
DR Proteomes; UP000199500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR004688; Ni/Co_transpt.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR PANTHER; PTHR31611; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR PANTHER; PTHR31611:SF0; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR Pfam; PF03824; NicO; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362101};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Reference proteome {ECO:0000313|Proteomes:UP000199500};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362101};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362101};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362101}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
SQ SEQUENCE 105 AA; 11438 MW; 898BAFCC348581FA CRC64;
MNFVHGWAFS KPVRKAFDKM ADTGLSVAVA LIIGTIELIS ILVDRLGIEP GPLAALGGLD
LDYVGYTIVG LFVLTWIVAL TVWRYGRIED KWTAASPPRH PDAMA
//
