ID A0A1H3MY42_9RHOB Unreviewed; 878 AA.
AC A0A1H3MY42;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05444486_10460 {ECO:0000313|EMBL:SDY81506.1};
OS Lentibacter algarum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Lentibacter.
OX NCBI_TaxID=576131 {ECO:0000313|EMBL:SDY81506.1, ECO:0000313|Proteomes:UP000199026};
RN [1] {ECO:0000313|EMBL:SDY81506.1, ECO:0000313|Proteomes:UP000199026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24677 {ECO:0000313|EMBL:SDY81506.1,
RC ECO:0000313|Proteomes:UP000199026};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FNPR01000004; SDY81506.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3MY42; -.
DR STRING; 576131.SAMN05444486_10460; -.
DR Proteomes; UP000199026; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000199026}.
FT DOMAIN 705..721
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 631..638
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 878 AA; 95418 MW; 70E047BF077AFEC6 CRC64;
MSAAKPTVTP MMAQYLEIKG NYPEALLFYR MGDFYEMFFD DAVAASEALD IALTKRGKHD
GEDIAMCGVP HHAAENYLLT LIRKGFRVAV CEQLESPEEA KKRGYKSVVR RDVVRLVTPG
TLTEDSLLEA RRNNFLAAYI EIRDVAGLAW LDMSTGDFRV MELSRVRLGP ELARLSPSEI
VFADAQFNEL APLAEEQGVA VSELGKASFD SEGAQKRLCT FFEVETLDAF GQFSRAEVSA
LGAVLDYLEI TQKGKLPLLA APVREVAGRV MQIDAATRRN LELTRSMQGA RAGSLLGAID
RTLTAQGARL LERRVSSPSC DVAEISARLD AVSVGLADTG FLADTRDSLR HVPDMERALS
RLGLERGGPR DLASIRNGLG KAGDIGSNMA KLELPTLLRE AGQKLLGHDA LVDLLDAALV
AEPPLFARDG GFVAAGYDEE LDASRALRDE GRGVIAKMQA DYAADTGIAA LKIKHNNVLG
YFIEVTATHA EKMLGAPLNE RFKHRQTTAN QVRFTTPELN EMETRILNAG GRATEIELRI
FGELRGAILA EQEAVFAATG ALAEIDLALG LASIAREEDW ARPSVDMSHA LEISQGRHPV
VEQALRRQGS TSFVPNDCVL AEDDQLWLLT GPNMAGKSTF LRQNALIAVL AQMGSYVPAV
AARVGIVSQL FSRVGASDDL ARGRSTFMVE MVETAAILNQ ADERALVILD EIGRGTATYD
GLSIAWATLE HLHESNHCRA LFATHYHEMT QLSDKLERCS NATVMVKEWE GDIIFLHEVR
KGVADRSYGV QVAKLAGLPE SVIARARVVL DALEKGEREG SAKAVIDDLP LFSATPAPAP
VKAKESEVEG ALADVFPDEL TPREALAVLY ELKAKMAK
//
