ID A0A1H3PMZ3_9BACI Unreviewed; 576 AA.
AC A0A1H3PMZ3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase {ECO:0000313|EMBL:SDZ02564.1};
GN ORFNames=SAMN05421736_105128 {ECO:0000313|EMBL:SDZ02564.1};
OS Evansella caseinilytica.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Evansella.
OX NCBI_TaxID=1503961 {ECO:0000313|EMBL:SDZ02564.1, ECO:0000313|Proteomes:UP000198935};
RN [1] {ECO:0000313|Proteomes:UP000198935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SP {ECO:0000313|Proteomes:UP000198935};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FNPI01000005; SDZ02564.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3PMZ3; -.
DR STRING; 1503961.SAMN05421736_105128; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000198935; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR025288; DUF4080.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF18; RADICAL SAM SUPERFAMILY PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF13311; DUF4080; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000198935}.
FT DOMAIN 1..133
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 172..405
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 576 AA; 66961 MW; EB0C06806EB413B8 CRC64;
MKIVVTTLNA KYIHTCLALR LLKAYAAPKY DVEMVEFTIK DPEVHVVSDL FARSPDVIGF
SCYIWNIEKT IQIVSMLKKV LPETKIILGG PEVSYDTEQW MARIKEADFI VRGEGEETFK
QLLRQIETDG AYDTIAGLAF RKDGSIVLTP SRPNLDITKI PTPYRFPQDR DSLGKRIVYF
ETSRGCPFQC QFCLSSIEVG VRYFPMEQVK SDLLYLINNG AKMIKFIDRT FNIKRDYALE
IFQFLIDNHG GCQFQFEITA DIMRPEVLEF LNKHAPAGIF RFEIGVQSTN DHTNDLVKRR
QNFNKLARTV TLVKEGKKID QHLDLIAGLP EENYASFRKT FNDVFALRPE ELQLGFLKML
RGTGMRAMAE QFGYQYMDHA PYEILSNNVL SFAEMTRIKR AEDILEKFWN QHYLDHTVEY
LIDHVFETPF DFFQQFGDFW DEQGWGKIGH QFDELFTRLF QFLQGIETKQ LALIEGLMKV
DYLLHYRHKP RKKWWSPTVA KDELPELSGG VLKQFLSGQG LSKHVIVEKI PFHAAEWIRC
RRLVEGPHLF IVHYDPKATR PVYYTETITD AGRLSS
//
