ID   A0A1H3R1F0_9ACTN        Unreviewed;       353 AA.
AC   A0A1H3R1F0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=TIR domain-containing protein {ECO:0000313|EMBL:SDZ19507.1};
GN   ORFNames=SAMN05660209_04992 {ECO:0000313|EMBL:SDZ19507.1};
OS   Geodermatophilus africanus.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Geodermatophilus.
OX   NCBI_TaxID=1137993 {ECO:0000313|EMBL:SDZ19507.1, ECO:0000313|Proteomes:UP000198921};
RN   [1] {ECO:0000313|EMBL:SDZ19507.1, ECO:0000313|Proteomes:UP000198921}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45422 {ECO:0000313|EMBL:SDZ19507.1,
RC   ECO:0000313|Proteomes:UP000198921};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNOT01000028; SDZ19507.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3R1F0; -.
DR   STRING; 1137993.SAMN05660209_04992; -.
DR   OrthoDB; 3654490at2; -.
DR   Proteomes; UP000198921; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        227..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          36..174
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
SQ   SEQUENCE   353 AA;  38394 MW;  EB083356BFF0565F CRC64;
     MHQAVISTAG AGGKPHLSIY SAASCRGGAM AGLGGIFISY RREDTADATG RLADLLVDRF
     GSARVFMDVN NIEPGQDFIR RINTAIAACD VLLVPIGSKW LAVDKNGQPR ICGPDDLVSL
     EIRAALERRI VVIPILIDGA AMVGSTRLPE GLKDLARRHA VLLRHASFAA DAERIIQLLD
     RVLATAELRR EDRRSQLNPS PSPDDSSDPA DEIWSLLVKR VKRRKRLWWG TYSLSILLAT
     APASIINPSD DGPFAIVSTM LVLATGLVWC VWKLQSEIAN QRLLVDQLPV NAQVEPIRRA
     LSRRHIIQMA MICLLVSLLF GVGMVVSPPD PGPETTGARA LPALTARLDY GIR
//