ID A0A1H3S9Y7_9PSEU Unreviewed; 431 AA.
AC A0A1H3S9Y7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=Concentrative nucleoside transporter, CNT family {ECO:0000313|EMBL:SDZ34812.1};
GN ORFNames=SAMN05216215_10627 {ECO:0000313|EMBL:SDZ34812.1};
OS Saccharopolyspora shandongensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=418495 {ECO:0000313|EMBL:SDZ34812.1, ECO:0000313|Proteomes:UP000199529};
RN [1] {ECO:0000313|EMBL:SDZ34812.1, ECO:0000313|Proteomes:UP000199529}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.3530 {ECO:0000313|EMBL:SDZ34812.1,
RC ECO:0000313|Proteomes:UP000199529};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033}.
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DR EMBL; FNOK01000062; SDZ34812.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3S9Y7; -.
DR STRING; 418495.SAMN05216215_10627; -.
DR Proteomes; UP000199529; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..80
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 90..188
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 194..428
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
SQ SEQUENCE 431 AA; 44568 MW; E86041C67A5A4284 CRC64;
MQVLWGIGGM LVVLLLAFAL STDRRAINPR TVIGALLIQI AFAVIVLRWD LGKQVLSAAA
DGVQKVISSS TEGIEFMVGP ILPSQGTVVA FQVLPIIIFI SALTAVLYHL NVLQWVVRII
GGGLQKVLGT TRPESLNSTA NIFLGLTEAP LTIRPYLKTM SRSEFFAVMV GGLATVAGTV
MVGYAMLGAK LENLIAASFM AAPAGLLMAK IVMPAAKEQP APAGSAAAES PAEGTVATET
AEEEGQAVAT KTAVEAEVEE KPRNVIDAAA GGAADGLKLA MNVGAMLFAF VSLIALVNLI
VGGVGGLFGL PDLTLQQILG YLFSPLMWVI GVPWHEAVAA GGFVGEKLVI NEFVAFADFG
PQIGQFSAKS ATIITFALTG FANFGSLAIL LGGLGSLVPS RRGWIAKDGV RAIMAATLAN
LLSATIAGVL V
//
