ID   A0A1H3SA73_9MICO        Unreviewed;       384 AA.
AC   A0A1H3SA73;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
GN   ORFNames=SAMN05216554_3412 {ECO:0000313|EMBL:SDZ34401.1};
OS   Herbiconiux ginsengi.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Herbiconiux.
OX   NCBI_TaxID=381665 {ECO:0000313|EMBL:SDZ34401.1, ECO:0000313|Proteomes:UP000198891};
RN   [1] {ECO:0000313|EMBL:SDZ34401.1, ECO:0000313|Proteomes:UP000198891}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.3491 {ECO:0000313|EMBL:SDZ34401.1,
RC   ECO:0000313|Proteomes:UP000198891};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|RuleBase:RU003862};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU003862}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|RuleBase:RU003862}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNPZ01000003; SDZ34401.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3SA73; -.
DR   STRING; 381665.SAMN05216554_3412; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000198891; Unassembled WGS sequence.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   InterPro; IPR022026; MTHFR_C.
DR   Pfam; PF12225; DUF5981; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003862};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU003862};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003862};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198891}.
FT   DOMAIN          10..39
FT                   /note="Methylene-tetrahydrofolate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12225"
SQ   SEQUENCE   384 AA;  39574 MW;  3A2A8541DE719977 CRC64;
     MVVTTEQRLA CPKHMEYGPC GGVEFDGSCE VGDFRCVFLE TPTVRWHGIA PNPLSPTGVA
     NAAIEGAGAA TGHAVVAAGH ASVDVHHLAD AHEFPVAPQR GAAAMRALLA ARPIVVADFP
     GRSVDRASLT DCAQALAGRV DATLAGDSGR SRVQFSPSYR AQLVQNEGLA VWTGLNCRDR
     NRVALEGELA GLADVGVAGV HCVTGDHTAT GNRHDALPVF DLDSTQLTAL ARQAGHLVSV
     AEAPLTPPVD RRAARLHEKV LAGADVCFVN HSGGVEPVRR FIAESHGLGI APAFIPCVPM
     VIDAGSASLL KSFTTLVLPE GFLDGILHAA HPYDAALDAI TRLCEEFLAV DGVAGVNLSG
     GPAAGAEVAF ADAMGVVAER LGLG
//