ID A0A1H3SDS6_9FIRM Unreviewed; 781 AA.
AC A0A1H3SDS6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SDZ36142.1};
GN ORFNames=SAMN05660462_02850 {ECO:0000313|EMBL:SDZ36142.1};
OS Proteiniborus ethanoligenes.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Proteiniborus.
OX NCBI_TaxID=415015 {ECO:0000313|EMBL:SDZ36142.1, ECO:0000313|Proteomes:UP000198625};
RN [1] {ECO:0000313|EMBL:SDZ36142.1, ECO:0000313|Proteomes:UP000198625}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21650 {ECO:0000313|EMBL:SDZ36142.1,
RC ECO:0000313|Proteomes:UP000198625};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
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DR EMBL; FNQE01000042; SDZ36142.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3SDS6; -.
DR STRING; 415015.SAMN05660462_02850; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000198625; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000198625}.
FT DOMAIN 6..203
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 206..306
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 381..416
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 490..608
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 781 AA; 88263 MW; 8A5357ED73465EC1 CRC64;
MYYIRKVAVL GSGLMGAGIA AHLANCGLEV ILLDIAPKEL NEDEKKKGLT LNHKEVKNRL
VLNARERMKD KKSMLLYTGE NIDLIKFGNL EDDLELLREV DWVIEAVVEN EKIKKELYEK
IQMYLKEDAF ISTNTSGISV NSLSEALNKE LKDRFFVTHF FNPPRHMKLL EIIPSNHTKP
EILEYMTLFC ENKLGKGVVI AKDTPGFIAN RIGIYSLGLI IHKIYQHNLT FEEADALTGT
EIGRPKTGTF RLLDMIGNDT ALFVAEYLKE NIKELKEKEI LNFPSYIKEM VNKGYLGDKT
KLGFYKKEGK DILVLEPETF NYRPKKKVEF IELEEAKKAK TLKEKLQTLV YGEGKPGNFL
WDVIKNTLLF TAGLVPEISD SIKDIDNAMK WGFNWEVGPF ELWDLIGVRK STEKMKMEGE
TIPPIVNELL NSGKEQFYSD KKLDLNSKNI SANSLKEQGK VIINNDHASL IDMGDNVACF
VLHSPNSSVT GEVVEFTHKA ISEVEKNYKG MIISSIGKNF CVGANLPFIL NSAREKKWDT
IDELVSDFQN MNMAIKYSSK PIVAAPYGMA LGAGAEITMH CSQARSFAEL YIGLVEVGVG
LLPGGGGTKE LLIKSQENIN DNKNIDLTPL VLKNFETITT GKVSKSEPDA KKIGYLRSMD
KIIMNKDRQL FTAKNDVLHL FENPKNNNRN KKIRVGGEGL YALLKYSTYQ MYKGGFITEY
EHYLANKIGY VLCGGNIPNN SMVDEQYLLD LEREAFVSLC GEQKTQERIE HMLKTGRPLR
N
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