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Database: UniProt
Entry: A0A1H3SDS6_9FIRM
LinkDB: A0A1H3SDS6_9FIRM
Original site: A0A1H3SDS6_9FIRM 
ID   A0A1H3SDS6_9FIRM        Unreviewed;       781 AA.
AC   A0A1H3SDS6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SDZ36142.1};
GN   ORFNames=SAMN05660462_02850 {ECO:0000313|EMBL:SDZ36142.1};
OS   Proteiniborus ethanoligenes.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Proteiniborus.
OX   NCBI_TaxID=415015 {ECO:0000313|EMBL:SDZ36142.1, ECO:0000313|Proteomes:UP000198625};
RN   [1] {ECO:0000313|EMBL:SDZ36142.1, ECO:0000313|Proteomes:UP000198625}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21650 {ECO:0000313|EMBL:SDZ36142.1,
RC   ECO:0000313|Proteomes:UP000198625};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
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DR   EMBL; FNQE01000042; SDZ36142.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3SDS6; -.
DR   STRING; 415015.SAMN05660462_02850; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000198625; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198625}.
FT   DOMAIN          6..203
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          206..306
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          381..416
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          490..608
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   781 AA;  88263 MW;  8A5357ED73465EC1 CRC64;
     MYYIRKVAVL GSGLMGAGIA AHLANCGLEV ILLDIAPKEL NEDEKKKGLT LNHKEVKNRL
     VLNARERMKD KKSMLLYTGE NIDLIKFGNL EDDLELLREV DWVIEAVVEN EKIKKELYEK
     IQMYLKEDAF ISTNTSGISV NSLSEALNKE LKDRFFVTHF FNPPRHMKLL EIIPSNHTKP
     EILEYMTLFC ENKLGKGVVI AKDTPGFIAN RIGIYSLGLI IHKIYQHNLT FEEADALTGT
     EIGRPKTGTF RLLDMIGNDT ALFVAEYLKE NIKELKEKEI LNFPSYIKEM VNKGYLGDKT
     KLGFYKKEGK DILVLEPETF NYRPKKKVEF IELEEAKKAK TLKEKLQTLV YGEGKPGNFL
     WDVIKNTLLF TAGLVPEISD SIKDIDNAMK WGFNWEVGPF ELWDLIGVRK STEKMKMEGE
     TIPPIVNELL NSGKEQFYSD KKLDLNSKNI SANSLKEQGK VIINNDHASL IDMGDNVACF
     VLHSPNSSVT GEVVEFTHKA ISEVEKNYKG MIISSIGKNF CVGANLPFIL NSAREKKWDT
     IDELVSDFQN MNMAIKYSSK PIVAAPYGMA LGAGAEITMH CSQARSFAEL YIGLVEVGVG
     LLPGGGGTKE LLIKSQENIN DNKNIDLTPL VLKNFETITT GKVSKSEPDA KKIGYLRSMD
     KIIMNKDRQL FTAKNDVLHL FENPKNNNRN KKIRVGGEGL YALLKYSTYQ MYKGGFITEY
     EHYLANKIGY VLCGGNIPNN SMVDEQYLLD LEREAFVSLC GEQKTQERIE HMLKTGRPLR
     N
//
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