ID A0A1H3VLV8_9RHOB Unreviewed; 964 AA.
AC A0A1H3VLV8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316, ECO:0000256|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000256|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156, ECO:0000256|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000256|HAMAP-Rule:MF_00205};
GN ORFNames=SAMN05444370_101194 {ECO:0000313|EMBL:SDZ75739.1};
OS Rubrimonas cliftonensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Rubrimonas.
OX NCBI_TaxID=89524 {ECO:0000313|EMBL:SDZ75739.1, ECO:0000313|Proteomes:UP000198703};
RN [1] {ECO:0000313|EMBL:SDZ75739.1, ECO:0000313|Proteomes:UP000198703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15345 {ECO:0000313|EMBL:SDZ75739.1,
RC ECO:0000313|Proteomes:UP000198703};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000, ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00205}.
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DR EMBL; FNQM01000001; SDZ75739.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3VLV8; -.
DR STRING; 89524.SAMN05444370_101194; -.
DR Proteomes; UP000198703; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd03270; ABC_UvrA_I; 1.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00205};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00205}; Reference proteome {ECO:0000313|Proteomes:UP000198703};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_00205};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW Rule:MF_00205}.
FT DOMAIN 624..952
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT ZN_FING 755..781
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 39..46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 656..663
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
SQ SEQUENCE 964 AA; 105613 MW; 86A9861F63BAB1D5 CRC64;
MADGRIPERR YLSVRGARAH NLKSIDVDIP RDALTVVTGL SGSGKSSLAF DTIYAEGQRR
YVESLSAYAR QFLQMMQKPD VDHIEGLSPA IAIEQKTTSR NPRSTVGTVT EVYDYLRLLY
ARVGTPHSPA TGLPIEAQQI SEMVDRVMAM PEGSRAYLLA PFVRDRKGAY AKEFVDLRKQ
GFQRVKVNGE FLDLDEAPVL DKKLRHDIDV VVDRIVVREG LETRLADSFA TALKLADGIA
IIETAPAADD EGNTPEPERF TFSEKFACPV SGFTIAEIEP RLFSFNAPFG ACPACDGLGA
ELYFDERLVV PDDGLSLGQG ALAPWSKTKT PYFRQTIDAI AKHYGFKTST PWRKLPPFAQ
QVMLHGSGED EIRFRYDDGG RVYEVVRGFE GVIPNMERRY RETDSAWVRE EFERYQAKRA
CGACGGYRLK EQALAVKIGG RHIGQVTEMA IREALDWVRD APNHLTKQKN EIATAILKEI
RERLGFLVNV GLDYLTLARN AGTLSGGESQ RIRLASQIGS GLTGVLYVLD EPSIGLHQRD
NDRLLTSLKG LRDQGNTVLV VEHDEEAIRE ADHVLDIGPG AGVHGGQVIA SGTPADIAAC
PASITGAYLR GDREIATPFE RRKGNGKHVR VVNATGNNLT GVTESIPLGV FTCITGVSGG
GKSTFTIETL YKTAAMRLNG ARETPAPCDR IEGFEHLDKV IDIDQSPIGR TPRSNPATYT
GAFGPIRDWF AGLPEAKTRG YQPGRFSFNV KGGRCEACQG DGVIKIEMHF LPDVYVECET
CKGARYNRET LEVLYKGKSI AQVLDMTVED GVGFFEAIPS IRDKLATLER VGLGYIKIGQ
QATTLSGGEA QRVKLSKELS KRATGRTLYI LDEPTTGLHF EDVKKLLEVL HELVETGNTV
VVIEHNLDVI KTADWLIDFG PEGGDGGGRI VATGTPEDVA AAPDSHTGRY LRPMLARAGR
IAAE
//
