ID   A0A1H3VR19_9BURK        Unreviewed;       507 AA.
AC   A0A1H3VR19;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:SDZ76694.1};
GN   ORFNames=SAMN05421875_101302 {ECO:0000313|EMBL:SDZ76694.1};
OS   Acidovorax soli.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Acidovorax.
OX   NCBI_TaxID=592050 {ECO:0000313|EMBL:SDZ76694.1, ECO:0000313|Proteomes:UP000199002};
RN   [1] {ECO:0000313|EMBL:SDZ76694.1, ECO:0000313|Proteomes:UP000199002}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25157 {ECO:0000313|EMBL:SDZ76694.1,
RC   ECO:0000313|Proteomes:UP000199002};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; FNQJ01000001; SDZ76694.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3VR19; -.
DR   STRING; 592050.SAMN05421875_101302; -.
DR   Proteomes; UP000199002; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          7..185
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          188..285
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          415..494
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   507 AA;  54620 MW;  53853C79A57E7956 CRC64;
     MKNQFSTIGI VGAGAMGRGI AQIAAQAGSR VLLLDMQPDA AESARQSIQA QWQRLLEKGR
     ISSEQMTHWA SQLQPAAAVA DLASCDLVIE AIVERLDAKQ ALFKQLEAVV GPQAVLATNT
     SSLAVTAIGA ALQRPERLAG FHFFNPVPLM KVVEVIGGLK TAPAVCEALA QYARQMGHTP
     VQAQDTPGFI VNHAGRGFGT EALRIVSEGV ADFATIDRIL RDQAGFKLGP FELLDLTALD
     VSHPVMESIY HQYYEEPRFR PSVITAQRLA GGMLGKKVGE GFYRYENGVA QIPTEPAAPE
     VSSIPPVWVS PRAARRAELY QLLKDLGASI ETGTSPSQTA ISLVAPLGFD ITTVAVVERL
     DPARTIGIDM LIDDAATRRR VLATNPATRV DIRDAAHALF ARDGKAVSVI RDSGGFVTQR
     VVATIVNIAS DICQQQICSP RDLETAVTLG LGYPLGPLAM GDRWGPTNIL EVLFNMQTVY
     GDPRYRPSPW LRRRGAIGLS LAHVEEH
//