ID A0A1H3VZI6_9FLAO Unreviewed; 629 AA.
AC A0A1H3VZI6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=NhaP-type Na+/H+ or K+/H+ antiporter {ECO:0000313|EMBL:SDZ80295.1};
GN ORFNames=SAMN05421540_101359 {ECO:0000313|EMBL:SDZ80295.1};
OS Psychroflexus halocasei.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Psychroflexus.
OX NCBI_TaxID=908615 {ECO:0000313|EMBL:SDZ80295.1, ECO:0000313|Proteomes:UP000198820};
RN [1] {ECO:0000313|EMBL:SDZ80295.1, ECO:0000313|Proteomes:UP000198820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23581 {ECO:0000313|EMBL:SDZ80295.1,
RC ECO:0000313|Proteomes:UP000198820};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FNQF01000001; SDZ80295.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3VZI6; -.
DR STRING; 908615.SAMN05421540_101359; -.
DR Proteomes; UP000198820; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR PANTHER; PTHR32507:SF0; NA(+)_H(+) ANTIPORTER 2-RELATED; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198820};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 25..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 411..514
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT REGION 609..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..629
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 69350 MW; B93ADD605364DB2E CRC64;
MVELAGIIIL GILAQWFAWR LKIPAILPLI LIGLIVGPVA TLFTPDNTKL IEPIWNGESG
LFPGESLYYF VSLAIAIILF EGGLTLRRSE ILNVGPVIVK LITIAVAITF AGAGIAAHFI
LGLSWQISLL FSALIIVTGP TVISPILRNI PLKKDVSSIL KWEGILIDPI GALVAVLVFE
FIMAGKGEAY TTTALIEFGK IVLFGFTFGF TFAHALSFAV KKKVIPHYLL NVFTLATVLG
VFVLADQFAH ESGLLAVVVM GIIMGHTNLP NLKELLYFKE SLSVLLISIL FILLAANINY
EDLLLVYNWE TLILFVVVVF IVRPLGVFLS SINSTLEFNE KLFISWVGPR GIVAAGIASL
FGLKLMNQNI PNAELITPLV FTIVLGTVLL NATTARPIAK LFGVFLTDAQ GILIVGSSSF
SRLIAQYLKD NKRHVVIVDN NKSNIEKAKQ KGIDAIHANI YSDDLIDNIE LSDVGYMMAL
TGNTSVNKKA IENFAKTFGE HGTYRVISSE EMEDPEQNPE EGLFSHTDDY IKLVNLSRRF
PKINEIDLNS EEHYRGLVEI SKVDSDIIPL FIKNEDGKLN IINSNSVDIE IDQGSVLVYL
GKEFKQEESK EVTKDEEEID VEIDEEKTE
//
