ID A0A1H3W1G9_9FIRM Unreviewed; 714 AA.
AC A0A1H3W1G9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=SAMN02745687_00557 {ECO:0000313|EMBL:SDZ80906.1};
OS Lachnospiraceae bacterium NK3A20.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=877406 {ECO:0000313|EMBL:SDZ80906.1, ECO:0000313|Proteomes:UP000199449};
RN [1] {ECO:0000313|EMBL:SDZ80906.1, ECO:0000313|Proteomes:UP000199449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NK3A20 {ECO:0000313|EMBL:SDZ80906.1,
RC ECO:0000313|Proteomes:UP000199449};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; FNQX01000008; SDZ80906.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3W1G9; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000199449; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SDZ80906.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199449};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 3..138
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 492..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 80984 MW; B9385595791FD483 CRC64;
MGKTVFIAEK PSVAESFAKA LHIKFTRRDG YEEAQNTIVT WCFGHLVTMS YPDAYDEKYK
RWSLATIPFI PDTYKYEVIN DAGVKKQFKI VKGLLTSPDV DTIYICTDSG REGEYIYRLV
ANQAGVRDKK QLRVWIDSFT DAEIIRGIKA AKDDSEYDNM GAAAYLRAKE DYLMGINFSR
ALSLKYARGI RDFLGMDHCV IAVGRVMTCV LGIVVKRERE IRAFQKTPFY RVMGSFSPMG
EDAGAAPEGA FSAEWSVQAK SRYHESPLLY KDNGFKEKKD AEALISYLED SSNGDNTAVV
HSITHKKETK NPPLLYNLAE LQNDCSRFFK ISPDETLNAA QALYEAKLTT YPRTDARVLS
TAVAKEIDTN LKGIGSLPLY RDLVREIAES GSWKKIAKTK YTNDKAITDH YAIIPTGQGY
QNLAKLPTTY QKVYELIVRR FLSVFYPAAI YDRMQLQVAV KTEILSASLR VNKDRGYLKC
LEYSFFKKKE QAETAEDKGE SGDDEGREED PSLEKFIRQL KKGDRLQTRG YEIREGETTP
PKRYNSGSMI LTMENAGQFI ENEELREQIK GSGIGTSATR AGILAKLVDN QYLNLNKKTQ
IYTPTQLGEM IYDAVDVSIR PLLDPKLTAS WEKGLTQVAE GTTSEEEYQK KLDDYITRRT
NLVKQSDNGA LLNQLYRRDA QYYPKPMKFK AKYTYTKYKG STGAQRKHSA SKDS
//
