ID   A0A1H3WA45_9FIRM        Unreviewed;      1460 AA.
AC   A0A1H3WA45;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=CoA-substrate-specific enzyme activase, putative {ECO:0000313|EMBL:SDZ83284.1};
GN   ORFNames=SAMN05216349_101266 {ECO:0000313|EMBL:SDZ83284.1};
OS   Oribacterium sp. KHPX15.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Oribacterium.
OX   NCBI_TaxID=1855342 {ECO:0000313|EMBL:SDZ83284.1, ECO:0000313|Proteomes:UP000199483};
RN   [1] {ECO:0000313|EMBL:SDZ83284.1, ECO:0000313|Proteomes:UP000199483}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KHPX15 {ECO:0000313|EMBL:SDZ83284.1,
RC   ECO:0000313|Proteomes:UP000199483};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR   EMBL; FNRG01000001; SDZ83284.1; -; Genomic_DNA.
DR   Proteomes; UP000199483; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199483}.
FT   DOMAIN          6..252
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          321..575
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          693..936
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1460 AA;  162952 MW;  DCCA95DE3A3EF2CF CRC64;
     MQRNRLGIDI GSTTVKIAIM DQEDKLLFSD YRRHHADIQG TLADILEEAK KQLGEISLST
     VITGSGGLTL SKHMDAAFCQ EVVAVATALK AYRPDTDVAI ELGGEDAKII YFKGGIDQRM
     NGICAGGTGS FIDQMASLLH TDAAGLNVLA KDYQMIYPIA ARCGVFAKTD IQPLINEGAA
     REDLAASIFQ AVVNQTISGL AQGKPIRGHV AFLGGPLHFM PELRKAFIRT LNLQGDEIIE
     PENSHLFAAI GSCLNCPEEA KEESVTQLIN MLRNGIKMDA EIKRMDPLFG NEKEYKEFSA
     RHDKAKVKTA DLSQYHGNVY LGIDAGSTTT KLALVSEEGE LLYRFYRNNN GSPIATAIES
     MKEIRDLLPE DARIAYSCST GYGEALLKSA FQLDEGEVET ISHYYAASFF DPKVDCILDI
     GGQDMKCIRI KDGTVDSVQL NEACSSGCGS FLETFAKSLD YSVIDFAHAA LYADNPTDLG
     SRCTVFMNSN VKQAQKEGAT VNDISAGLAY SVIKNALFKV IKVTEAKDLG EHIVVQGGTF
     YNDAVLRAFE NLLGANVVRP DIAGIMGAFG AALIARERYH MANEKIKNMK PTEEIKVPLT
     AYGRVQTTML PLSEIINLKY TTKMTRCQGC NNHCVLTVNQ FGAGRNYISG NRCERGLGKT
     KIKRDIPNLF EYKLKRMFDY EPLPQDIAVR GEVGIPRVLN MYENYPFWAT FFRELKFRTV
     LSPASTRKIY ELGIESIPSE SECYPAKIVH GHIEWLIRNG QKFIFYPCIP YERNETPDAG
     NHYNCPMVTS YAENIKNNVE GLEDNSVMFM KPFLAFTDEK ICTDQLVRIF IHGGEIERSI
     RPVGELTDSK IEEQFKAWNI TEDEVRAAAH EAWLELERAH TDMQKKGEET LHWMKETGHR
     GIVLAGRPYH VDPEIHHGIP ELITSYDFAV LTEDSVSHLA EVERPIIVTD QWMYHTRLYR
     AAEFVKHRED VDLIQLNSFG CGLDAVTVDQ VRDILTGSDK IYTVLKIDEV NNLGAARIRV
     RSLIAAIRVR DEKNYVRNIR PANYERKLFT KEMKAKNYTI LCPQMSPIHF EIVEAAFRAA
     GYNLIVLNNA NRSAIDTGLK YVNNDACYPS IIVVGQIMEA LNSGKYDPNE TAVIMTQTGG
     GCRASNYIGF IRRALEHAGM SQIPVISLNT NSMESTPGFK LTLPLLTRAM QAVVYGDVFM
     RVLYATRPYE AVPGSAEALH QKWLKVCKMA VSKKTTSMSL FKKNVKGIIR DFDNLPLKEG
     LVKPKVGIVG EILVKFSPLA NNHIVELLEN EGAEAVMPDL MDFLLYCFYN QNFKYENLGA
     GWKGKALCNC AINFLEYFRK TARKEFTKSR RFTPPGEIKE LAKMAREYVS IGNQTGEGWF
     LTGEMLELME EGVNNIVCTQ PFGCLPNHIV GKGVIKELKK HNPDANIIAV DYDAGASEVN
     QLNRIKLMLT VAQNKLKEQA
//