ID A0A1H3XAW5_9BACT Unreviewed; 919 AA.
AC A0A1H3XAW5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Aconitate hydratase {ECO:0000256|RuleBase:RU361275};
DE Short=Aconitase {ECO:0000256|RuleBase:RU361275};
DE EC=4.2.1.3 {ECO:0000256|RuleBase:RU361275};
GN ORFNames=SAMN05660909_00360 {ECO:0000313|EMBL:SDZ96433.1};
OS Chitinophaga terrae (ex Kim and Jung 2007).
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Chitinophaga.
OX NCBI_TaxID=408074 {ECO:0000313|EMBL:SDZ96433.1, ECO:0000313|Proteomes:UP000199656};
RN [1] {ECO:0000313|Proteomes:UP000199656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23920 {ECO:0000313|Proteomes:UP000199656};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis-
CC aconitate. {ECO:0000256|RuleBase:RU361275}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336,
CC ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023501,
CC ECO:0000256|RuleBase:RU361275};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 2/2. {ECO:0000256|ARBA:ARBA00004717}.
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185, ECO:0000256|RuleBase:RU361275}.
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DR EMBL; FNRL01000001; SDZ96433.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3XAW5; -.
DR STRING; 408074.SAMN05660909_00360; -.
DR OrthoDB; 9764318at2; -.
DR UniPathway; UPA00223; UER00718.
DR Proteomes; UP000199656; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd01586; AcnA_IRP; 1.
DR CDD; cd01580; AcnA_IRP_Swivel; 1.
DR Gene3D; 6.10.190.10; -; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR044137; AcnA_IRP_Swivel.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR006249; Aconitase/IRP2.
DR InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR NCBIfam; TIGR01341; aconitase_1; 1.
DR PANTHER; PTHR11670; ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER; 1.
DR PANTHER; PTHR11670:SF54; CYTOPLASMIC ACONITATE HYDRATASE; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR PROSITE; PS00450; ACONITASE_1; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|RuleBase:RU361275};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU361275};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU361275};
KW Lyase {ECO:0000256|RuleBase:RU361275};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 57..576
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 706..832
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
SQ SEQUENCE 919 AA; 101097 MW; 44145FAD5D611F11 CRC64;
MEPKIALLSK LEQEGKQISR LPFSIRILLE NVLRNKDNFA ITDEHVETLV NWTPGGTDKE
VPFKPARVLM QDFTGVPAVV DLASIRAEVI RQGKDGAAIN PAIPVDLVVD HSVQVDFFGT
DYSYRKNVAY EYERNKERYQ LLKWAQQAFR NFTVVPPGMG ICHQVNLEYL AKGVISRDGW
IFPDTLVGTD SHTPMVNGIG VLGWGVGGIE AEAAILGQPI YFTCPQVIGL KLTGKLTEGV
TATDMVLAIT ELLRKYGVVD KFVEVFGDGL DHLTVPDRAT ISNMSPEFGC TVTYFPVDDQ
TLQYMRRTNR PADQISLVES YCRQNMLWRN GDENITYSDI LELDLNKVQA AVAGPKRPQD
RILVKDLGNE FETLLGKEYK RMYTPEGKRR DTAWLSEGGS GTTFTYEIQK PLEDVAVEVD
YLKSVRVKLR NEEYVLSDGA ITIAAITSCT NTSNPSVMIG AGLVAKKAIS RGLTVKPWVK
TSLAPGSRVV TDYLKRANLL EELEALRFHV VGYGCTSCIG NSGPLPPAIA EAVDKGNLVV
ASVLSGNRNF EARVHPQVKM NFLASPMLVV AYAIVGRVDI DLLTAPLGYD PNGEPVYLRD
IWPTQEEINQ AIATAVKQED FENAYSVIFD GDEQWQGLLA PTGNNYHWSN DSTYIREAPF
FKGISSQLEP LHDITGARVL LKLGDSVTTD HISPAGSFKS DTPAGKYLLD HGIDQRMFNS
YGSRRGNHEV MVRGTFANVR LKNDLSPKEG GYTTLMPSGT VLSVYDASVK YAASGTPLIV
LAGKEYGSGS SRDWAAKGTN LLGVKAIIAE SYERIHRSNL VGMGILPLEY MNGQNAASLN
LTGTEQYDIT GLEGGLTPGK VLKVKAIPGS GEPPVEFDVK CKLNSEIEIE YYLNGGILQY
VLRDFLARGF TQNVSRREA
//
