ID   A0A1H3Y1T1_9BURK        Unreviewed;       303 AA.
AC   A0A1H3Y1T1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=DNA ligase-1 {ECO:0000313|EMBL:SEA05480.1};
GN   ORFNames=SAMN05444680_101354 {ECO:0000313|EMBL:SEA05480.1};
OS   Variovorax sp. YR216.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=1882828 {ECO:0000313|EMBL:SEA05480.1, ECO:0000313|Proteomes:UP000199122};
RN   [1] {ECO:0000313|Proteomes:UP000199122}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YR216 {ECO:0000313|Proteomes:UP000199122};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
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DR   EMBL; FNRO01000001; SEA05480.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3Y1T1; -.
DR   STRING; 1882828.SAMN05444680_101354; -.
DR   Proteomes; UP000199122; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07896; Adenylation_kDNA_ligase_like; 1.
DR   CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR   Gene3D; 3.30.1490.70; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR029319; DNA_ligase_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR47810; DNA LIGASE; 1.
DR   PANTHER; PTHR47810:SF1; DNA LIGASE B; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF14743; DNA_ligase_OB_2; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000313|EMBL:SEA05480.1}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..39
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           40..303
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011587162"
FT   DOMAIN          63..219
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|Pfam:PF01068"
FT   DOMAIN          234..298
FT                   /note="DNA ligase OB-like"
FT                   /evidence="ECO:0000259|Pfam:PF14743"
SQ   SEQUENCE   303 AA;  33737 MW;  A56EF1CC81C286D0 CRC64;
     MSFSFRMGRD VLMAITRRWF LLAAAGAAFG LAHVTDAAAQ PAQKVPAPVM LAEVYHPGVA
     LDDYWVSEKY DGIRGYWDGK QLWTRSGERI AAPRWFTEAL PAEPLDGELW AGRGRFSQTV
     STVRSQPPSD TAWREIRFMV FDVPAQPGDF TARLAYLRKL LPITSVPWVV AVPQQRATTA
     EDLDALLEKT MKLGGEGLML HRGASHYHAE RSNDLLKVKA YDDAEARVVE HIGGRGKHGG
     RLGALLVEMP NGKRFKLGGG LTDAERENPP PVGTWVTYRY NGTNPSGVPR FARFLRVRED
     MDF
//