ID A0A1H3Y5C3_9FIRM Unreviewed; 616 AA.
AC A0A1H3Y5C3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Uncharacterized radical SAM protein YgiQ {ECO:0000313|EMBL:SEA06022.1};
GN ORFNames=SAMN05216349_10479 {ECO:0000313|EMBL:SEA06022.1};
OS Oribacterium sp. KHPX15.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Oribacterium.
OX NCBI_TaxID=1855342 {ECO:0000313|EMBL:SEA06022.1, ECO:0000313|Proteomes:UP000199483};
RN [1] {ECO:0000313|EMBL:SEA06022.1, ECO:0000313|Proteomes:UP000199483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KHPX15 {ECO:0000313|EMBL:SEA06022.1,
RC ECO:0000313|Proteomes:UP000199483};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01251};
CC Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC cysteines and an exchangeable S-adenosyl-L-methionine.
CC {ECO:0000256|HAMAP-Rule:MF_01251};
CC -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000256|HAMAP-
CC Rule:MF_01251}.
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DR EMBL; FNRG01000004; SEA06022.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3Y5C3; -.
DR Proteomes; UP000199483; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR HAMAP; MF_01251; UPF0313; 1.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR InterPro; IPR022946; UPF0313.
DR InterPro; IPR024560; UPF0313_C.
DR InterPro; IPR013704; UPF0313_N.
DR NCBIfam; TIGR03904; SAM_YgiQ; 1.
DR PANTHER; PTHR32331; UPF0313 PROTEIN YGIQ; 1.
DR PANTHER; PTHR32331:SF0; UPF0313 PROTEIN YGIQ; 1.
DR Pfam; PF11842; DUF3362; 1.
DR Pfam; PF08497; Radical_SAM_N; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01069; UPF0313; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|HAMAP-Rule:MF_01251};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|HAMAP-Rule:MF_01251};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|HAMAP-
KW Rule:MF_01251};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_01251}; Reference proteome {ECO:0000313|Proteomes:UP000199483};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_01251}.
FT DOMAIN 295..566
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 597..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 309
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01251"
FT BINDING 313
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01251"
FT BINDING 316
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01251"
SQ SEQUENCE 616 AA; 70202 MW; DE0D29D4D31F80D2 CRC64;
MFEGFLPINK KDMLDRGWEQ PDFVYVCGDA YVDHSSFGAA IISRVLEAHG YKVAMLPQPD
WNNPSSVTEF GEPRLGFLVS AGNMDSMVNH YTVAKRHRKT DAYTPGGVMG KRPDRAATVY
CNLIRKTYKH TPIIIGGIEA SLRRLAHYDY WSDSIRRSIL LDSGADLISY GMGEHSIVEI
ADALNSGLQV KDITWIPGTV YKTRHEDEIY DAVRLPDFED IKSSKRKYAE SFATQYRNTD
PISAKRIYEC YDGAMFVVQN PPAAPLTEME MDDVYALPFM RAWHPIYDKD GGIPAFGEIK
ESITQARGCF GECNFCALTM HQGRIVQVRS HESVLEEAKQ ITKDPEFKGY IFDVGGPTAE
FRGPACDKQL KHGACVNKKC LWPEPCKNLK VDHSDYVKML REVRSLPGVK KVFVRSGFRF
DYLMADSNKE FLKEICKYHV SGQMRVAPEH VSDNVLKEMG KPGVNVYNSF VKEFEKINRE
LGLNQYIVPY LMSSHPGSRL KDAITLAEYI RDMGYIPEQV QDFYPTPGTV STTMYYTGLN
PLTMEEVYVP KNPHEKAMQR ALIQYKKPEN YELVKEALLR EHREDLIGFG PECLIRPRAQ
KPEKTGSKPR NKFKSR
//
