ID A0A1H3YEM1_9FIRM Unreviewed; 459 AA.
AC A0A1H3YEM1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Serine protease Do {ECO:0000313|EMBL:SEA09987.1};
GN ORFNames=SAMN02745687_01748 {ECO:0000313|EMBL:SEA09987.1};
OS Lachnospiraceae bacterium NK3A20.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=877406 {ECO:0000313|EMBL:SEA09987.1, ECO:0000313|Proteomes:UP000199449};
RN [1] {ECO:0000313|EMBL:SEA09987.1, ECO:0000313|Proteomes:UP000199449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NK3A20 {ECO:0000313|EMBL:SEA09987.1,
RC ECO:0000313|Proteomes:UP000199449};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; FNQX01000023; SEA09987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3YEM1; -.
DR OrthoDB; 1765023at2; -.
DR Proteomes; UP000199449; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF129; SERINE PROTEASE HTRA2, MITOCHONDRIAL; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SEA09987.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199449};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 351..436
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT REGION 69..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 48884 MW; 903C606CA9AF32C9 CRC64;
MTGEDKELKE VNTDFMKEKI KARPVNKRKL LRRTITTACL AALFGAVACV AFLVLEPVIN
RAINPEEPQQ VSIPEETSEE ISPEDMIASD EARQKQETEE AVSQAVSQIG IDTNSIKQEI
KDELAKEMES TSGYKEMYDG LAEAAVKAQE SIVSVKSITP DYDWAGDAYD QTGSSSGLIV
AATSEDVLIL APGDILKSAR RIEVTFPDDA VAAATIRAVD SVTGMAVIAV DRKDLSEETH
GSFGTAVFGS SQRINLLGRP VIAVGSPTGS LGSVAYGVVT NAQLPLDMTD SSYAQLTTDI
YGSTRASGVL VDTNSEVIGW IDDSHNAKDT PNLLSAIGIT ELKPLIERMS NGEGLAGAGF
HGTAVPEEVQ KEQGVPAGAY ITRVEIDSPA MKAGLQSGDI VTGFGLTQIG DYQQLITALS
NAQPGRDVPL TIMRQGADRY EEAELTLTPE NRLQAADNS
//
