ID A0A1H3YMW1_9FIRM Unreviewed; 715 AA.
AC A0A1H3YMW1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN04515656_10432 {ECO:0000313|EMBL:SEA12906.1};
OS Eubacterium aggregans.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=81409 {ECO:0000313|EMBL:SEA12906.1, ECO:0000313|Proteomes:UP000199394};
RN [1] {ECO:0000313|EMBL:SEA12906.1, ECO:0000313|Proteomes:UP000199394}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SR12 {ECO:0000313|EMBL:SEA12906.1,
RC ECO:0000313|Proteomes:UP000199394};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FNRK01000004; SEA12906.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3YMW1; -.
DR STRING; 81409.SAMN04515656_10432; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000199394; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199394}.
FT DOMAIN 12..287
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 288..547
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 715 AA; 81017 MW; 25A0F42CC69B650C CRC64;
MDLTQYLERY AITLNAQQLE AMERIQGATL LLAVPGSGKT TVIICRLGYM IRELGISEDQ
ILTLTFSRAG ARDLGQRYRS ILGGEGAAPR FSTIHSFALS VIRTYERQTG RRAFDVLQDV
GAVIRALFRQ VFKSYPSDND IADILSAITY TKNLMLNKEE IAALKVGDLD FPRIYTAYEQ
YKRKAHLMDF DDMLRYAWLL LKKYPALLAH FTERYRYINV DEAQDTSKIQ FELIHLLVAR
WGNLFMVGDE DQSIYGFRGA YPQGLLDFET QYPQGKVLLM ETNYRSTGAL VASANRFITL
NQERYPKKMT TPNALGVPAV QEYVKTLEDQ YRFLLNSVQK EGKETAVLYR NNESAIPLVD
LFERQGVPYR LKEHNPLFFS HFVVRDILDF LALSEDPGDG EIFEKSYYKM NCGISKENMI
QAIRQKKPGE TVFHALYTLP GIPEWLVERV QTQEAGFQRL KTLPMNRVVD YIEHQLGYGE
HLAYRVEMGC REEQLTQKME ILKTLAKREE TRDGFRRRLS DLAAILRGET ESKGRGVLLS
TIHSSKGLEF EKVFIIDAVD GEFPSRAALE PTEEGERLMN EEIRLFYVGV TRAKGELEFI
SVGQKGRYNP TRPVSRFVEH YLGRRPVAKA AEKPITGGKS PGKRGLSMGT ASVRPEVMPK
AAVPDHWGVG TIITHGGFGP GEITALEGET ATVRFERAGA KKLNLAICLS KGIIE
//
