ID   A0A1H3Z562_9FIRM        Unreviewed;       509 AA.
AC   A0A1H3Z562;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   ORFNames=SAMN04515656_1059 {ECO:0000313|EMBL:SEA18422.1};
OS   Eubacterium aggregans.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=81409 {ECO:0000313|EMBL:SEA18422.1, ECO:0000313|Proteomes:UP000199394};
RN   [1] {ECO:0000313|EMBL:SEA18422.1, ECO:0000313|Proteomes:UP000199394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SR12 {ECO:0000313|EMBL:SEA18422.1,
RC   ECO:0000313|Proteomes:UP000199394};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR   EMBL; FNRK01000005; SEA18422.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3Z562; -.
DR   STRING; 81409.SAMN04515656_1059; -.
DR   OrthoDB; 9761056at2; -.
DR   Proteomes; UP000199394; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   NCBIfam; TIGR00795; lctP; 1.
DR   PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199394};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        6..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        32..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        63..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        131..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        159..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        181..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        210..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        238..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        278..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        326..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        369..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        402..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        489..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
SQ   SEQUENCE   509 AA;  52652 MW;  E34D51058F54457C CRC64;
     MDNQILLFFL ALVPIVWLIV SLGVLKMPGH IACSIALVIT LLLSILVWKF SFVNALTGAL
     EGIVMGLWPI VYIIIAAVFT YNLTTASGSM DTIKKMMTGV SSDKRILVLI LAWGFGGFLE
     AIAGFGTAVA IPAGIMAALG FGPVVAAVMC LIANTTPTAF GAIGLPVTTL AQVAGLDVMH
     LSYVVTIQLF VLILIIPFVL VAIAGGGVKA IKGVFGITLA SGLAFALPQI VVAKFIGAEL
     PAIVGSICCL GVTIFIAKKF YHRDAESADG DKVSAKEGFI AWLPFIFVFL LIILCSSLVP
     PINHALNMVK TSIPIYTGEG AKPYTFAWLA CPGTLIIIAT FLGGLCQGMS FKEIAVVLGK
     TVKQMAKTAI TVCSIVGLAK VMGYSGMISV IAAVLVALTG NVYPLIAPII GALGTFVTGS
     DTSANVLFGQ LQVEAAQAIG ADPYWIAAAN MAGATAGKMI SPQSIAVATA ATGLIGQEGR
     ILGSTIKYCA AYVVLIGLVV FLGGPLLGF
//