ID A0A1H3ZFI8_9GAMM Unreviewed; 917 AA.
AC A0A1H3ZFI8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05660964_01153 {ECO:0000313|EMBL:SEA22181.1};
OS Thiothrix caldifontis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Thiotrichaceae; Thiothrix.
OX NCBI_TaxID=525918 {ECO:0000313|EMBL:SEA22181.1, ECO:0000313|Proteomes:UP000199397};
RN [1] {ECO:0000313|EMBL:SEA22181.1, ECO:0000313|Proteomes:UP000199397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21228 {ECO:0000313|EMBL:SEA22181.1,
RC ECO:0000313|Proteomes:UP000199397};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FNQP01000005; SEA22181.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3ZFI8; -.
DR STRING; 525918.SAMN05660964_01153; -.
DR REBASE; 494435; Tca21228ORF1153P.
DR Proteomes; UP000199397; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR046818; MmeI_C.
DR InterPro; IPR046819; MmeI_hel.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR046817; MmeI_N.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF6; DNA METHYLTRANSFERASE A; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20467; MmeI_C; 1.
DR Pfam; PF20465; MmeI_hel; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF20464; MmeI_N; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SEA22181.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199397};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 24..188
FT /note="MmeI-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20464"
FT DOMAIN 194..272
FT /note="MmeI-like helicase spacer"
FT /evidence="ECO:0000259|Pfam:PF20465"
FT DOMAIN 356..612
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 636..837
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
FT DOMAIN 839..915
FT /note="MmeI-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20467"
SQ SEQUENCE 917 AA; 104454 MW; 7F3C885EEBD3EC59 CRC64;
MILAFDSGLI FMAALSNRKT IRGNALAFVK EWGNETREEA EAKSFWDAFF AIFGVNRKSV
AAFEHAVERT DNTKGFIDLF WKGVLLVEHK SRGKSLDKAK SQAFDYFQQI KDQRDRPRYV
LLSDFARFKL YDLDRRLEHD IAIDDLPDKI EFFDFMAGLD NHGESIQEYA LNIKAAERLG
KLHDALQDAG CAGHELEVFL VRILFCLFAE DTGIFSRHQF YNYLEHFTAP DGSDTDSRLN
KLFQTLDKPV NARGKHLLAE LNDFPYVNGH LFREILDLPS FDADMREALL DCSHFDWGSI
SPAIFGSLFQ SVMDKAARRE LGAHYTSETH ILRLIKPLFL DALWAEFSAI QQGGNRDKRK
KLAAFQQRLT ALQFLDPACG CGNFLIITYR ELRRLELAVL QAQHGDAHRG LEITVEPTIK
LEHFHGIEIE EWPVRIAEVA MWLTQHQMNR EFARQFGREP DLLPLKSSAH IVIGNSLQLD
WAAVVKPANL NHIIGNPPFR GSKMQSDAQK QELATLFGKV QNAKQLDYVA CWFKKTADFI
QKTRISVAFV STNSITQGEQ VAPLWQPLLD IGIHLHFAHR TFSWDSEARG KAAVHVVIVG
FAAFDTDGKR IFDYPAIKGE PVEIAASNIN PYLIDAPDVV LDSRNQPLGN VSPMWFGNMP
LDGGALLLSS TEKAELLEKE PNAEKWLKLC LGADEFINGK ERWCLWLVGI APNELRAMPE
VLKRIEQVKK FRLASVAAST RVHAERPTEF RDTRLPKTYI LVPSVSSERR EYVPMGFFDS
NTISTNLNLM IPDASLYEFG VLESKIHMAW MRTVCGRLKS DYRYSAKLVY NNFPWPDADD
KQRKKVEAAA QAVLDARKNY PTSTLADMYD PTSMPPDLRK AHTALDKAVD QCYRKEKFGS
DMERLTWLFE RYRGLVG
//
