ID A0A1H3ZGF2_9FIRM Unreviewed; 718 AA.
AC A0A1H3ZGF2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05216349_10720 {ECO:0000313|EMBL:SEA22402.1};
OS Oribacterium sp. KHPX15.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Oribacterium.
OX NCBI_TaxID=1855342 {ECO:0000313|EMBL:SEA22402.1, ECO:0000313|Proteomes:UP000199483};
RN [1] {ECO:0000313|EMBL:SEA22402.1, ECO:0000313|Proteomes:UP000199483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KHPX15 {ECO:0000313|EMBL:SEA22402.1,
RC ECO:0000313|Proteomes:UP000199483};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FNRG01000007; SEA22402.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H3ZGF2; -.
DR Proteomes; UP000199483; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199483}.
FT DOMAIN 6..293
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 294..561
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 718 AA; 82603 MW; 4DFDE9461ED064A3 CRC64;
MEDVLVGLNE AQTEAVTTTE GFVRVIAGAG SGKTRALTHR FAYLVNDLGV LPGNILCVTF
TNKAANEMRQ RIHQLTGDND TGYINTFHGF CVNILQEDSH AISYPKSFMV LDNGDIDEML
KIIYEERGLT LRDKTYGNAR DMFEIRKCLS EPEYYLDMIQ LPIDKLYQKY MDAESVDDIL
FYGYLYQQRK TFAVDYNDLI ILSLYIFREN PDIALKWQKR LEYIEIDEFQ DIDPLQYKLM
EVLCGYHKNL FIVGDPDQTI YTWRGANVKY LLDFDKHYPG TKTIMMLENY RSTPQILKVC
NSLISKNKQR MSKDLVPVLQ DGVPVVCHLA ENAEGEAKWI VKNIETLHQM GVDYKDMTCL
YRAHYVTRTL EEVFLKSQIP YTIYSGVQFF GRMEIKDALC YLRMIVFKDD LSFRRIANVP
KRNLGVRRMK FLEDYTKEHG CSLYEALVKN IEDEIFKGTE AARFIAMIEK YAATYEDKTI
SEVLGSILNE SGYERMLRTE GSQERLDNLA ELKQSVFEFE TSAGEETDLS GYLKNVAMFS
NMDKADATDR VKLMTVHTAK GLEFPYVFLC SLSEGIFPSK KTNTLEGMEE ERRLAFVAMS
RAEKGLYLSE AAGKNFDGSP RYPSRFILDI DPVLLSFTEA PRAGLISETQ SYINLVNSRL
RKPDDSELFS IGDRIAHKAF GLGTIKDVNM DKNAYTIQFD DMPTERQISF RVKLQKCK
//