ID   A0A1H3ZJY9_9FIRM        Unreviewed;       366 AA.
AC   A0A1H3ZJY9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=4-hydroxythreonine-4-phosphate dehydrogenase {ECO:0000313|EMBL:SEA23975.1};
GN   ORFNames=SAMN05216349_10780 {ECO:0000313|EMBL:SEA23975.1};
OS   Oribacterium sp. KHPX15.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Oribacterium.
OX   NCBI_TaxID=1855342 {ECO:0000313|EMBL:SEA23975.1, ECO:0000313|Proteomes:UP000199483};
RN   [1] {ECO:0000313|EMBL:SEA23975.1, ECO:0000313|Proteomes:UP000199483}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KHPX15 {ECO:0000313|EMBL:SEA23975.1,
RC   ECO:0000313|Proteomes:UP000199483};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the PdxA family. PdxA2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009464}.
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DR   EMBL; FNRG01000007; SEA23975.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3ZJY9; -.
DR   Proteomes; UP000199483; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR005255; PdxA_fam.
DR   PANTHER; PTHR30004; 4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR30004:SF6; D-THREONATE 4-PHOSPHATE DEHYDROGENASE; 1.
DR   Pfam; PF04166; PdxA; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199483}.
SQ   SEQUENCE   366 AA;  39855 MW;  1ACC411184103DFD CRC64;
     MADIRPIVGI SMGDPFGNGP EISVKALNDK TLYDRCKPLI VGDKTSMEYA LKVAQKVNGI
     DLKLNIVKEP EEGKYEYGTI DLIDLNLVPD DKIPDTLDDP DGPQPFHVGA CELGGEAAFQ
     YVVYVIKLAM ADKVDATVTN ALSKEAINMA GHHYSGHTEI YADYTNTKKY AMMLGHEDLR
     VVHVSTHVSL REACDRVKKD RVLDCIHMAN EACKALGIAE PKIGVAGLNP HCGEDGMFGR
     EEIEEIQPAI DEALKEGINI PEKKPTPPDT VFSKALGGWY DIVVVMYHDQ GHIPLKVKGF
     VYNKDEHHWE AVAGINMTLG LPIVRVSVDH GTGFGHAGNG GANELSLVNA VDAALQMASY
     RKANKA
//