ID   A0A1H3ZQE6_9FIRM        Unreviewed;       200 AA.
AC   A0A1H3ZQE6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Signal peptidase (SPase) II {ECO:0000313|EMBL:SEA25908.1};
GN   ORFNames=SAMN02745687_02309 {ECO:0000313|EMBL:SEA25908.1};
OS   Lachnospiraceae bacterium NK3A20.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=877406 {ECO:0000313|EMBL:SEA25908.1, ECO:0000313|Proteomes:UP000199449};
RN   [1] {ECO:0000313|EMBL:SEA25908.1, ECO:0000313|Proteomes:UP000199449}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NK3A20 {ECO:0000313|EMBL:SEA25908.1,
RC   ECO:0000313|Proteomes:UP000199449};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A8 family.
CC       {ECO:0000256|ARBA:ARBA00006139, ECO:0000256|RuleBase:RU004181}.
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DR   EMBL; FNQX01000037; SEA25908.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H3ZQE6; -.
DR   Proteomes; UP000199449; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR001872; Peptidase_A8.
DR   PANTHER; PTHR33695; LIPOPROTEIN SIGNAL PEPTIDASE; 1.
DR   PANTHER; PTHR33695:SF1; LIPOPROTEIN SIGNAL PEPTIDASE; 1.
DR   Pfam; PF01252; Peptidase_A8; 1.
DR   PRINTS; PR00781; LIPOSIGPTASE.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199449};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        105..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          51..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   200 AA;  21900 MW;  932EC67C4735D1FF CRC64;
     MKKRDWVYPA LTAAVLITDQ LLKSAARTRI LEGETVPLQL TKKRRYLEIS HGDSHVDGNS
     STDNGSRRPE HSGNVRESSS HALLLARNSR NRGAAMNLMQ RHPGIVMMIS AGYTLALTIL
     FAVTLGHAGG DVLKAGLSLL LGGAYSNTYD RLRRRYVTDY VSFNFGPKFL RNIVYNIGDF
     AIAVGALLLV IGANKSNEVT
//