ID A0A1H4A9I3_9FIRM Unreviewed; 390 AA.
AC A0A1H4A9I3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Radical SAM additional 4Fe4S-binding SPASM domain-containing protein {ECO:0000313|EMBL:SEA32341.1};
GN ORFNames=SAMN02745687_02514 {ECO:0000313|EMBL:SEA32341.1};
OS Lachnospiraceae bacterium NK3A20.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=877406 {ECO:0000313|EMBL:SEA32341.1, ECO:0000313|Proteomes:UP000199449};
RN [1] {ECO:0000313|EMBL:SEA32341.1, ECO:0000313|Proteomes:UP000199449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NK3A20 {ECO:0000313|EMBL:SEA32341.1,
RC ECO:0000313|Proteomes:UP000199449};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FNQX01000051; SEA32341.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H4A9I3; -.
DR OrthoDB; 9810775at2; -.
DR Proteomes; UP000199449; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR017200; PqqE-like.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR PIRSF; PIRSF037420; PQQ_syn_pqqE; 1.
DR SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000199449};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 1..209
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 390 AA; 43715 MW; 9BE867077B9BC232 CRC64;
MFVPRTAVWE ITMACNMRCK HCGSSCSKPL DNELTTAEAL SLCDQLADLG LKRITLSGGE
PTTRGDWLNI AERLIQNGIT TSIITNGWSM SQEMVSNIKN VGLKSVAISL DGVKETHDSI
RKVGSFEKSM NLISMLVEAG ITVSAITTIN KQNLDELDAL FNILAQKGVY SWQLQFALPM
GNFKNHIDKM IAPEDIKSII DFAYSKIEKE PMIVLADCLG YYSKNSIQIT ERFLQDKWSW
TGCGAGKSVI GILCDGSIVG CTSIRDRKLV AGNIRNQSLR SIWGNPDSFR WNREFSNKQL
KGFCKECQYS EICKGGCSNS RYCLTGSFES ENKYCSYNAS YYSLKTLLRS FNKESQFTNL
LERADGNSDF NKLISDEYRR FTARDSHVSE
//
