ID   A0A1H4B2A5_9FIRM        Unreviewed;       414 AA.
AC   A0A1H4B2A5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=GHKL domain-containing protein {ECO:0000313|EMBL:SEA42273.1};
GN   ORFNames=SAMN02910384_01502 {ECO:0000313|EMBL:SEA42273.1};
OS   Pseudobutyrivibrio sp. ACV-2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Pseudobutyrivibrio.
OX   NCBI_TaxID=1520801 {ECO:0000313|EMBL:SEA42273.1, ECO:0000313|Proteomes:UP000199179};
RN   [1] {ECO:0000313|Proteomes:UP000199179}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACV-2 {ECO:0000313|Proteomes:UP000199179};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNQZ01000005; SEA42273.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4B2A5; -.
DR   STRING; 1520801.SAMN02910384_01502; -.
DR   OrthoDB; 9813149at2; -.
DR   Proteomes; UP000199179; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd16935; HATPase_AgrC-ComD-like; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032834; NatK_C.
DR   Pfam; PF14501; HATPase_c_5; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        32..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        60..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        116..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        149..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        178..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          305..410
FT                   /note="Sensor histidine kinase NatK C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14501"
SQ   SEQUENCE   414 AA;  47810 MW;  12274CAC3500D7E9 CRC64;
     MIAFHVSPFI VLIELVASIG VLLLWQEKRP LFALRVLLFA VILIGMNFTW DKFVFENLAY
     VIQFAVIVLA VLFCYNLNPV SALYWSTASL SIQHLAFSLL TLSSCFFYGI YSTPIYFILC
     YIIILTLEYL LITRHFGKDF ELRDKQIKLT IVSLIAMFSC TILNSYRMRY TNDNDLIFVT
     SIYSIICSLL ALFLQLGLFE KGQLEMEKSV LEQIIANDKR HYDDSLQNVE LLNMYCHDLK
     YFLRRNADEV GSFKHQAEKF LSTFDADIST YNHALDTILT EKSLYCANND IQLTCMADGQ
     LLEYMDTADV YAMFGNLLSN AIEAVSKLEN HEKRMISLTV RRRNDFVHIL VDNYYDNTLS
     FHNGLPESTK EQPHLHGYGL KSIRYLAEKY NGNLTISADE DVFHVNILMP INIQ
//