ID A0A1H4B2X1_9FIRM Unreviewed; 720 AA.
AC A0A1H4B2X1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093};
GN ORFNames=SAMN05216349_11229 {ECO:0000313|EMBL:SEA42471.1};
OS Oribacterium sp. KHPX15.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Oribacterium.
OX NCBI_TaxID=1855342 {ECO:0000313|EMBL:SEA42471.1, ECO:0000313|Proteomes:UP000199483};
RN [1] {ECO:0000313|EMBL:SEA42471.1, ECO:0000313|Proteomes:UP000199483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KHPX15 {ECO:0000313|EMBL:SEA42471.1,
RC ECO:0000313|Proteomes:UP000199483};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364093}.
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DR EMBL; FNRG01000012; SEA42471.1; -; Genomic_DNA.
DR RefSeq; WP_031549271.1; NZ_FNRG01000012.1.
DR AlphaFoldDB; A0A1H4B2X1; -.
DR Proteomes; UP000199483; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:SEA42471.1};
KW Cilium {ECO:0000313|EMBL:SEA42471.1};
KW Flagellum {ECO:0000313|EMBL:SEA42471.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000199483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 276..309
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 720 AA; 79349 MW; 6809B146B556D9A9 CRC64;
MKWTKFVADN SIVVMALVII LLLIIPLPPF MADLAIVLNM AISMMILVIT MTIHSPLEFS
IYPSLLLLTT LFRLGINVST TRNILSNGGS SGQVIAAFGD FVLQGNVVVG LVIYIVIVLM
NFTVITKGAE RVAEVSARFN LDAMPGKQMA IDSDLNAGLI DEQEAARRRM NVQRESDFYG
SMDGATKIVK GDGVMSLITT AINLVGGSII GIVQSGQDIG TVLNTYTIAT VGDGLVGQIP
SLLISTATGM IVTRAVAEGS LNEDISKEFL AQPRSFMVAG GVICVLCIIP GMPLIQILIV
GLGFIAAGYA MQRRILEAPE AVRAEAYRAA SQGARQRIGN VGVEEPEAAG EEQAQKAPEQ
TQEEFFKDVN NVYHLLQVEP IELNFGYSLI PLADESVGGR LISRIVVFRR QYAQEMGFVI
PSVRLRDSAK LGTNEYMIKI KGESVAVGEV LTDFYLALEP EHLEREIDGI DTIEPAYGIP
SKWIKPEQRE RAEMYGYTVI DPLSVLVSHM SEVIRQHSYE LITRQEVFRL VENLKKTAPE
LVNEAFPTLV SYNLLQKVLT MLLKEGVSIK DLETIVETMV DVITETGLPV KDIDSLVEQV
RISLKRTITR MYCEDGSMKV VTLDADLERS MVSSLSKGES GYYLALSPDV LQSLVRQVSE
EIKKFKELSQ TPVILTSEVM RAHFYHLIEQ FYPQVRVLSF NEVANNVQIQ AIGSLKLEEK
//
