ID A0A1H4BNA4_9BACT Unreviewed; 479 AA.
AC A0A1H4BNA4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=23S rRNA (Uracil1939-C5)-methyltransferase {ECO:0000313|EMBL:SEA49282.1};
GN ORFNames=SAMN04487851_10755 {ECO:0000313|EMBL:SEA49282.1};
OS Prevotella sp. tc2-28.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1761888 {ECO:0000313|EMBL:SEA49282.1, ECO:0000313|Proteomes:UP000199625};
RN [1] {ECO:0000313|EMBL:SEA49282.1, ECO:0000313|Proteomes:UP000199625}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TC2-28 {ECO:0000313|EMBL:SEA49282.1,
RC ECO:0000313|Proteomes:UP000199625};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
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DR EMBL; FNRE01000007; SEA49282.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H4BNA4; -.
DR STRING; 1761888.SAMN04487851_10755; -.
DR OrthoDB; 9804590at2; -.
DR Proteomes; UP000199625; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:GOC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.40.50.1070; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR030391; MeTrfase_TrmA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR NCBIfam; TIGR00479; rumA; 1.
DR PANTHER; PTHR11061:SF48; 23S RRNA (URACIL(747)-C(5))-METHYLTRANSFERASE RLMC; 1.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS50926; TRAM; 1.
DR PROSITE; PS01230; TRMA_1; 1.
DR PROSITE; PS01231; TRMA_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01024}; Reference proteome {ECO:0000313|Proteomes:UP000199625};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01024}.
FT DOMAIN 4..63
FT /note="TRAM"
FT /evidence="ECO:0000259|PROSITE:PS50926"
FT ACT_SITE 437
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 437
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 304
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 340
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 361
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 410
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 479 AA; 54672 MW; 93325E224CF9A8E7 CRC64;
MTRKKKPLPL LEHITITDYA AEGKSVARVD DMVVFVPWAV PGDVVDLQVR RKKHSFMEAE
VVRYHEYSKV RTQPFCQHFG VCGGCKWQQL PYEEQLKMKQ QQVYDQLTRI GKVKLPAFRP
ILGSVKTKEY RNKLDFGCAN KRWLTTEQLK DDTLVKDTPA IGFHITGAFD KILPIEKCWL
MDDLQNQIRN EVRDYAVEHG LSFFDLRQQV GLLRDVIVRN SASGEWMVII QFHFDETGGE
QEAQGLLQHI ADKFPQITSL LYLDNQKCND TIGDQDIRVF KGKDHIFELM EDLKFKVGPK
SFYQTNTEQA YHLYSVAREF AFGNLSSLSS DTSPLVYDLY TGTGTIANFV AKQARQVIGI
EYVPEAIEDA KINSEINGIK NTLFYAGDMK DILTDDFINA HGRPDVIITD PPRAGMHPDV
IKTILNAAPK RIVYVSCNPA TQARDLQALD EKYQVVEVQP VDMFPHTPHV ENVVLLTQK
//