ID   A0A1H4D5H3_9FIRM        Unreviewed;       727 AA.
AC   A0A1H4D5H3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Nucleoside-diphosphate-sugar epimerase {ECO:0000313|EMBL:SEA67964.1};
GN   ORFNames=SAMN05216349_12237 {ECO:0000313|EMBL:SEA67964.1};
OS   Oribacterium sp. KHPX15.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Oribacterium.
OX   NCBI_TaxID=1855342 {ECO:0000313|EMBL:SEA67964.1, ECO:0000313|Proteomes:UP000199483};
RN   [1] {ECO:0000313|EMBL:SEA67964.1, ECO:0000313|Proteomes:UP000199483}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KHPX15 {ECO:0000313|EMBL:SEA67964.1,
RC   ECO:0000313|Proteomes:UP000199483};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNRG01000022; SEA67964.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4D5H3; -.
DR   Proteomes; UP000199483; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199483};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        331..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        597..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          34..229
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   727 AA;  83927 MW;  44CFA73C45329614 CRC64;
     MKYIKTKEDS TSCILIAGNT NCLETETLNH IADYYRVVII SDDSDNVAPI KLSAKYSKRI
     KTYKEDLSSD NCKKIFHAFS PDTVWYFSGY TDGCDGLRDE NKKLSALIHN CSAIGVQKLI
     FISSVSSLNY YYKDTVNGKV KIYLSETGFE CSQLENLCRY SSTKNYLKYI ILRAPYLYSK
     YNNTKNYLGS LFSRMEEIEP IVFPYDASGK VDFLSVRDIT ELLMFITEET LDDAGTYTLT
     SDSGLTYQSF AELLKKCEPS TQASFSEGKP CVLELDEKNE NRNIRKEYGF IPLDNIVENL
     NDFYKIYIQG LNKEVNILEK LLERMPKLPH IALAVTETLV LFVIIQLLLP YTSDNTLFKY
     VDLRLFFVVI LGVTYGMIPG MLAGLLMCFS LIYSYSQIGI TIKMLFYNMD YWLPFAIYLM
     TGAITGYLVS TKDQKLKFAE DEAISLHNKY SFLNDVYMSV INNKEEYKRQ ILGYQDSFGK
     IFEAVHSLDS SVPEKIFMNS IETLENILDN HTIAIYTLDK FQRYGRLVAC SRELLTDQPK
     SLNIEQISDV YEVIKNRGTW KNIDFKEELP TYAYGILDEG KVRIMICIYK ASQMQMGLYY
     MNLFTIICHL IRFSFIRALR YQTLMEENKY FENTGILKPE FFISELKAQR NMADKGIASH
     VLLKLHSFNI VETDKKLGHL IRHTDSLGIG EDGKYYLLMR QINPNVFKII DQRLRENGIE
     FTVVEGV
//