ID   A0A1H4D7T6_9SPHI        Unreviewed;       596 AA.
AC   A0A1H4D7T6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Chloride channel protein, CIC family {ECO:0000313|EMBL:SEA68489.1};
GN   ORFNames=SAMN05443550_104351 {ECO:0000313|EMBL:SEA68489.1};
OS   Pedobacter hartonius.
OC   Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Pedobacter.
OX   NCBI_TaxID=425514 {ECO:0000313|EMBL:SEA68489.1, ECO:0000313|Proteomes:UP000198850};
RN   [1] {ECO:0000313|EMBL:SEA68489.1, ECO:0000313|Proteomes:UP000198850}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19033 {ECO:0000313|EMBL:SEA68489.1,
RC   ECO:0000313|Proteomes:UP000198850};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FNRA01000004; SEA68489.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4D7T6; -.
DR   STRING; 425514.SAMN05443550_104351; -.
DR   OrthoDB; 9812438at2; -.
DR   Proteomes; UP000198850; Unassembled WGS sequence.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd02205; CBS_pair_SF; 1.
DR   CDD; cd00400; Voltage_gated_ClC; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198850};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        64..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        199..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        229..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          534..594
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   596 AA;  65879 MW;  7FBC1C84FC0C1D8A CRC64;
     MYVRLVTYLD EINQYRRTKI SNRNFLVIAA LIVGILAGLA AALLKSLTHH IEDFLQDGFH
     WEYKYYLFLV FPLIGILLSV MYVRRFIRKG KFETGLTPIL YTISKKSSRV EPHNIYSQII
     TAALTVGFGG STGLEAPIVQ SGAGIGSVIG RFLGLSYRET TMLLACGAAA GIAGAFNSPI
     AGIVFAIEIL LPEFSIPAFI PLLLASATAA VVARFFYNEQ LFFLVTEGWE FNALIWYVVL
     AVLIGLFSIY FNKIYYFIKH IFHDIKAPYQ RVIAGGVVLG AMVFLFPTLY GEGYITIKNL
     LGGNYSTVIT NSIFSSYSNL PWAIILFTVI TLFAKSAATL ITLGAGGNGG IFAPSLIMGG
     LIGFVLAFTI NTLGIAHVNI ANFIVAGMAA SLSAIMHAPL TGIFLIAEIT GGYVLMVPLM
     ITSAIAYLIS RSQNKYSIYT KPLAESGELM SYEDKDSTVL HMMKLKYLLE NDYLVLNENE
     TIAERLPDIL NSKRNLFPVI AEDKTFKGLI YVEDVLKKAI HTPSADELSV HDLMQTAPDV
     LYINDSLKNV LSKMEKENAW LLPVLNEQEE YLGIVSKTAI FNKYRALLSR QADYME
//