ID A0A1H4DGM0_9MICO Unreviewed; 807 AA.
AC A0A1H4DGM0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=SAMN04515680_1275 {ECO:0000313|EMBL:SEA71698.1};
OS Leifsonia sp. 21MFCrub1.1.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leifsonia.
OX NCBI_TaxID=1798223 {ECO:0000313|EMBL:SEA71698.1, ECO:0000313|Proteomes:UP000198709};
RN [1] {ECO:0000313|Proteomes:UP000198709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=21MFCrub1.1 {ECO:0000313|Proteomes:UP000198709};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LT629867; SEA71698.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H4DGM0; -.
DR STRING; 1798223.SAMN04515680_1275; -.
DR OrthoDB; 9802472at2; -.
DR Proteomes; UP000198709; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04863; MtLigD_Pol_like; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR033649; MtLigD_Pol-like.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:SEA71698.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000198709};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 592..717
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 291..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 89152 MW; 36D273FBA025095D CRC64;
MAAQDTEVVE IDGHRLKLTN LDKVMYPETG TTKADIFGYY NAVADVMIPH VRDRIATRKR
WVHGVGTPDD PGEVFFQKNL DPASTPDWVR QASITHKTST NTYPLVNDRA TLIWLAQIAS
LEIHVPQWRV GRGGERRNPD RLVLDLDPGE GVTLVDCAEV ARLARAILTD MGLDPFPVTS
GSKGIHLYAA LDGSQTSDQI SAVAHELARA LEADHPDLVV SDMKKSLRAG KVLVDWSQNN
GAKTTIAPYS LRGRFHPTVA APRTWRELAS KKLEHLDYRE VLQRLKRRGD PLADLSAGDG
TSGHGGHVSE PDRLSTYRSM RDAAKTPEPV PDERPAAREG RSFVIQEHHA RRLHWDFRLE
NDGVLVSWAL PKGPPTDTKQ NHLAVHTEDH PLEYGGFAGD IPHGEYGAGH VDIWDHGDYE
LEKWRDDEVI ATLHGQPDGG LGGKPRKFAL IRTAQGGDEK NWLIHLMKTE GHDDHRTHRE
PGPAITGDPV SPMLATLGSP ADVTDEDEWA FEMKWDGIRA IAEVRGGRLR LTTRNGNDVT
STYPDLAGLV DLAGDHDLVL DGEIVTLNPQ GRPDFGLLQT RMGLTRPGDV QAALKRAPAH
YMVFDVLEVD GRKHTRDSYD ERRALLTEVL RPGRGDAVQV PPAFDGDLGH AIASSRELGL
EGVMAKRRDS TYATGRRSRS WIKIKHHLTQ EVVIGGWTPG NGRRADTIGA LLLGIPDGDT
LRYVGKVGTG FTDRVLDDLA AKLGAHERKT PPLEGVPSAD ARGAHWVRPE YVGEVEFAEW
TGPGRLRQPS WRGLRPDKRP DQVVRES
//
