ID   A0A1H4EZK7_ALKAM        Unreviewed;      1020 AA.
AC   A0A1H4EZK7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=diguanylate cyclase {ECO:0000256|ARBA:ARBA00012528};
DE            EC=2.7.7.65 {ECO:0000256|ARBA:ARBA00012528};
GN   ORFNames=SAMN04488051_108113 {ECO:0000313|EMBL:SEA90505.1};
OS   Alkalimonas amylolytica.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alkalimonas.
OX   NCBI_TaxID=152573 {ECO:0000313|EMBL:SEA90505.1, ECO:0000313|Proteomes:UP000198773};
RN   [1] {ECO:0000313|EMBL:SEA90505.1, ECO:0000313|Proteomes:UP000198773}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.3430 {ECO:0000313|EMBL:SEA90505.1,
RC   ECO:0000313|Proteomes:UP000198773};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNRM01000008; SEA90505.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4EZK7; -.
DR   STRING; 152573.SAMN04488051_108113; -.
DR   OrthoDB; 176203at2; -.
DR   Proteomes; UP000198773; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011110; Reg_prop.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR011123; Y_Y_Y.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR   PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF07494; Reg_prop; 2.
DR   Pfam; PF07495; Y_Y_Y; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 2.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198773};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1020
FT                   /note="diguanylate cyclase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011662179"
FT   TRANSMEM        736..757
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          834..973
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   COILED          772..799
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1020 AA;  117509 MW;  1F7217C89405FE9C CRC64;
     MILRWCWICL LFSFSLQAIE RSLHDYDIKH WDSSDGLASN SVRALTQDQQ GYIWAGTLYG
     LSRFDGYRFD TFTSQQYRQL ASNAINQLMT DSQGLIWIGT KSGLSRLNPN TLSFERFNIL
     SEVTAIAEVR PGEIWIAAEQ LFRIQAGQVS RISPVRQPVR QLRSSGDYVW LTTTEHLIRY
     ELESGQMQRY LLPRELQQNP IYDIALTDSQ VHLATEVGFY HLNSDGEVVR CDQLLQEYMA
     TYRIFRDSRG SDWISSYSRL HQRHQGHAWQ QISATELGSS PWFYDIFEDK DNNIWLASFS
     DGIFRASPGH VRRVVGEGQT DPVVRSLAVT PEQRLLIATQ SSLGYLSHQG HFQPLLDQQV
     LGSQSIHDIH FADDSWWLAM DNGLFRYEPG TEHISSLASE LDGSTVRFVQ PRHAGGLWVG
     GAAGLFFWQD QQLRPFAFNR ELESRHVTTI RDQNWYQVIG TTRGLYQLQQ QRLQRLGIGS
     PLYNSYIISL LVLPDETLLI GTFDDGLFVR FPNGEWRQFD NSNGLPYGPV VAMLLDEQQE
     QLWFSTLKGV FRLPLSSLSL LKQDPLQAEQ ILTPYQRQLG NTPGRCCNGA GHSKLVLWQD
     QLWFPTLQGV VAIDRFFQRR NDPDFRPLLQ QIVGQRSYLL QAQQQRQVLP VNERSFTIHY
     TALDFFNATS LQFRYRLRGF DKSWQQAASR REAIYTNLPP GHYYFEVQVR QQNQSWAEAQ
     SSQIELVVPR RFDETWMYQV LWFALLGLIL SGVFWLVRRN NQQQQLALSR LVRQRTQELE
     NSNNRLNELN AQLGQLVHKD TLTGLRNRRF LFEQLPKDIE HYQRNRLSLQ QQGKCVALIH
     LDLDGFKSIN DQYGQSAGDS LLQQISALLL RETRGSDYVV RYAGEEFLLV LRDIDISILW
     DFANKLHALV GSTRYPLPDG QRIQLTCSVG YSVYPLQLIG GQLMNWELSL QLAEMALYRV
     KHEGKDGVAT LVFDGRVDAF EFEESMHIEA QIEQLLSEGL AQFKIQAANH QGPISETDVP
//