ID A0A1H4F653_9BACT Unreviewed; 730 AA.
AC A0A1H4F653;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=SAMN05444145_10961 {ECO:0000313|EMBL:SEA92387.1};
OS Alistipes timonensis JC136.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC Alistipes.
OX NCBI_TaxID=1033731 {ECO:0000313|EMBL:SEA92387.1, ECO:0000313|Proteomes:UP000183253};
RN [1] {ECO:0000313|EMBL:SEA92387.1, ECO:0000313|Proteomes:UP000183253}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25383 {ECO:0000313|EMBL:SEA92387.1,
RC ECO:0000313|Proteomes:UP000183253};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; FNRI01000009; SEA92387.1; -; Genomic_DNA.
DR RefSeq; WP_010265845.1; NZ_FNRI01000009.1.
DR AlphaFoldDB; A0A1H4F653; -.
DR STRING; 1033731.SAMN05444145_10961; -.
DR GeneID; 78310952; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000183253; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.10.1390; ATP-dependent DNA helicase RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048671; RecQ-1-like_HTH.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF21220; RecQ-1-like_HTH; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SEA92387.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000183253}.
FT DOMAIN 30..201
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 221..378
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 532..612
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 730 AA; 82122 MW; 12B5E0A476193AB4 CRC64;
MKQFDSSLLH DKLKEYFGFS SFKGNQEAVI RNVLEGNDTF VLMPTGGGKS LCYQLPALLM
DGVAIVISPL IALMKNQVDA MRTFSAESGI AHFLNSSLNK TAVAQVRADV LAGKTKLLYF
APESLTKEDN VAFLHKIKVS FYAIDEAHCI SEWGHDFRPE YRRIRPIINE IGAAPLIALT
ATATPKVQLD IQKNLGMSDA SVFKSSFNRA NLYYEIRPKR NVDRDIIRFI KQNEGKSGII
YCLSRKKVEE LTELLVANGI RALAYHAGMD AVTRAANQDD FLMERVEVIV ATIAFGMGID
KPDVRYVIHY DIPKSLEGYY QETGRAGRDG GEGYCLTFYS YKDIQKLEKF MQGKPIAEQE
IGKLLLLETV SYAESSMCRR KTLLHYFGED YTEDNCGNCD NCRNPKPKVD AKAALKMALE
ALRDIGDKFK ADYLINVLVG KTTALIKSYG HNKSKWFGAG AEHDARFWGA VLRQALILGL
VDKNIENYGL ISVNKKGEGY IALPFPVTVT LDHDYDEEEK ESESVAPMGK GGAADEELFS
MLKDLRKKVA KQHGLPPFVI FQDPSLEDMA VQYPITFEEM QNITGVGVGK ARKFGEEFIK
LIKAYVEEKE IIRPQDMIVK GVASKSGNKI FIIQSIDRKM DFEDIARAKD LDFDELLTEI
EGIVNSGTKL DISYYLKGFM DEDKIEDIYL YFKEDAESDS LDMAIEELGA DYTEEEIRLV
RIKFMCEQGN
//
