ID A0A1H4FD21_9BACI Unreviewed; 771 AA.
AC A0A1H4FD21;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=SAMN05421743_11148 {ECO:0000313|EMBL:SEA95239.1};
OS Thalassobacillus cyri.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Thalassobacillus.
OX NCBI_TaxID=571932 {ECO:0000313|EMBL:SEA95239.1, ECO:0000313|Proteomes:UP000198584};
RN [1] {ECO:0000313|EMBL:SEA95239.1, ECO:0000313|Proteomes:UP000198584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM7597 {ECO:0000313|EMBL:SEA95239.1,
RC ECO:0000313|Proteomes:UP000198584};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
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DR EMBL; FNQR01000011; SEA95239.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H4FD21; -.
DR STRING; 571932.SAMN05421743_11148; -.
DR OrthoDB; 9803432at2; -.
DR Proteomes; UP000198584; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}; Reference proteome {ECO:0000313|Proteomes:UP000198584}.
FT DOMAIN 353..573
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 752..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..771
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 364..368
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 771 AA; 88084 MW; D48B6005D574AA6D CRC64;
METIDDKQQL ESGYIKGTLN RMIFHNESEH FSIASVRIKD TNEPIEEKDV VIKGHFSPLE
EGESYLFQGK IEQHPKFGQQ YQIDFYRRVL PESKDGLIAY LSSDLFQGIG KKTAEKIYQT
LGNQAVNSIL NDKNVLDNVP GMKKEQADRL YHALKEHQGF EHVVIHVSQY GFGLKMAQKI
YEVFKDESLS ILQEDPYQLV FHVEGFGFHR ADEVARVNQV PFDHPTRIRA ACLYILQQSY
QTGHVYLPTR DVLESLDRLL NGSQQGITFD HLSQQLIQMG EEGVVRIETD RIYLPSLFHA
ENGFCHQLDR ITAEKMDADY TQAELLKIIG SVEEEESLSY GQDQFQAIEK SLQSKVMILT
GGPGTGKTTV IKGIIRAYAE LNELSLNPDD YDQDEPFPFI LTAPTGRAAK RMTESTGLPA
RTVHRLLGWD GKNSFEKNQN NQLEGKVLIV DEFSMVDIWL ANQLFRAIPK DMQVLVVGDE
DQLPSVGPGQ VLTDMLGSEQ LPYVQLQEVY RQKEGSRIIQ LAHEIKNDNC TSQSLKKERD
FTFIDAKEHQ LVDVVTHIVK RAIDKGIEPR EIQVLAPMYR TQVGINKLNE EIQLLVNPPS
KQKRDIKFKE LVYRTGDKVI QLVNQPEDGV YNGDIGEIVA IFREDENVDQ VEQVVIDFDG
KEVVYPKKDL TNITHAYCTS IHKSQGSEFS IVILPVVRSY RRMLRKNLLY TAITRSKQSL
IICGDKQAFL EGVKTEDTNL RYTQLKEKLM ENNATPIPDE EEEEISPYDF M
//
