ID   A0A1H4GCW2_9BACI        Unreviewed;       104 AA.
AC   A0A1H4GCW2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Paired small multidrug resistance pump {ECO:0000313|EMBL:SEB07446.1};
GN   ORFNames=SAMN05421743_11548 {ECO:0000313|EMBL:SEB07446.1};
OS   Thalassobacillus cyri.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Thalassobacillus.
OX   NCBI_TaxID=571932 {ECO:0000313|EMBL:SEB07446.1, ECO:0000313|Proteomes:UP000198584};
RN   [1] {ECO:0000313|EMBL:SEB07446.1, ECO:0000313|Proteomes:UP000198584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCM7597 {ECO:0000313|EMBL:SEB07446.1,
RC   ECO:0000313|Proteomes:UP000198584};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003942};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003942}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       {ECO:0000256|RuleBase:RU003942}.
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DR   EMBL; FNQR01000015; SEB07446.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4GCW2; -.
DR   STRING; 571932.SAMN05421743_11548; -.
DR   OrthoDB; 21828at2; -.
DR   Proteomes; UP000198584; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3730.20; -; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561:SF0; GUANIDINIUM EXPORTER; 1.
DR   PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198584};
KW   Transmembrane {ECO:0000256|RuleBase:RU003942, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        84..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   104 AA;  11759 MW;  473DB922B4E1CC33 CRC64;
     MSWIYLIIAG AFEMSGVVMI NKVNRDRKLT TLLFMLLLMA SSFLFLKLAM QKLPMGTAYA
     VWTGIGTVGS TILGMVFYQE PRDWKRVFFI TVIIIATIGL RMVS
//