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Database: UniProt
Entry: A0A1H4JUV0_9MICO
LinkDB: A0A1H4JUV0_9MICO
Original site: A0A1H4JUV0_9MICO 
ID   A0A1H4JUV0_9MICO        Unreviewed;       283 AA.
AC   A0A1H4JUV0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN   ORFNames=SAMN04489806_0877 {ECO:0000313|EMBL:SEB50094.1};
OS   Microbacterium humi.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Microbacterium.
OX   NCBI_TaxID=640635 {ECO:0000313|EMBL:SEB50094.1, ECO:0000313|Proteomes:UP000199183};
RN   [1] {ECO:0000313|EMBL:SEB50094.1, ECO:0000313|Proteomes:UP000199183}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21799 {ECO:0000313|EMBL:SEB50094.1,
RC   ECO:0000313|Proteomes:UP000199183};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC         Evidence={ECO:0000256|ARBA:ARBA00000783,
CC         ECO:0000256|RuleBase:RU366031};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
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DR   EMBL; FNRY01000001; SEB50094.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H4JUV0; -.
DR   STRING; 640635.SAMN04489806_0877; -.
DR   OrthoDB; 9815856at2; -.
DR   Proteomes; UP000199183; Unassembled WGS sequence.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU366031};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199183}.
FT   DOMAIN          26..245
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   283 AA;  29791 MW;  B71DD67870CC14DF CRC64;
     MTTAPSKPLK GWRVLVPRGG PWGDGVAAEL RDRGATPVIA PMVNFAPTSD PEGLAQALKR
     LEAGYFDWVT LTSATTVDVL YTQNVTIPRR TKVAAVGETT AAALLAVGYH VDLVPAKDNS
     AKGMVSELTQ LEPTPKKFLT LRSEIAKPVL TKGLITAGHD VHSVVAYRTI GEPVTQKVRD
     DVASGRTNAI LVTSGSVAEQ VVEQLTPLPP TTLIAAIGPR TAKDAAKAGL AVHIVSRRQT
     VTDLLDAIVR VVESGGQDAA VTSTAQGEVI TSAIRIVEER NAQ
//
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