ID A0A1H4K671_9ACTN Unreviewed; 710 AA.
AC A0A1H4K671;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=alpha-galactosidase {ECO:0000256|ARBA:ARBA00012755};
DE EC=3.2.1.22 {ECO:0000256|ARBA:ARBA00012755};
GN ORFNames=SAMN04489844_0457 {ECO:0000313|EMBL:SEB54059.1};
OS Nocardioides exalbidus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=402596 {ECO:0000313|EMBL:SEB54059.1, ECO:0000313|Proteomes:UP000198742};
RN [1] {ECO:0000313|Proteomes:UP000198742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22017 {ECO:0000313|Proteomes:UP000198742};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC residues in alpha-D-galactosides, including galactose
CC oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001255};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNRT01000002; SEB54059.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H4K671; -.
DR STRING; 402596.SAMN04489844_0457; -.
DR OrthoDB; 9758822at2; -.
DR Proteomes; UP000198742; Unassembled WGS sequence.
DR GO; GO:0004557; F:alpha-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR CDD; cd14791; GH36; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 2.70.98.60; alpha-galactosidase from lactobacil brevis; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR038417; Alpga-gal_N_sf.
DR InterPro; IPR000111; Glyco_hydro_27/36_CS.
DR InterPro; IPR002252; Glyco_hydro_36.
DR InterPro; IPR031705; Glyco_hydro_36_C.
DR InterPro; IPR031704; Glyco_hydro_36_N.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43053:SF3; ALPHA-GALACTOSIDASE C-RELATED; 1.
DR PANTHER; PTHR43053; GLYCOSIDASE FAMILY 31; 1.
DR Pfam; PF16874; Glyco_hydro_36C; 1.
DR Pfam; PF16875; Glyco_hydro_36N; 1.
DR Pfam; PF02065; Melibiase; 1.
DR PRINTS; PR00743; GLHYDRLASE36.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS00512; ALPHA_GALACTOSIDASE; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 24..258
FT /note="Glycosyl hydrolase family 36 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16875"
FT DOMAIN 616..696
FT /note="Glycosyl hydrolase family 36 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16874"
FT REGION 57..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 76733 MW; E54CF2C9E10B2835 CRC64;
MNESVPTHLS RSGVSLVVGR DASGVPVVLH WGAGLGDVDD ATLLALEVAR RPGVSRSSYD
LPRRTGLVPD GTRGFSGTPG LAGHRVGGDA RAAAPSLVDW TVERDGDTLT CTSVDDEAGW
QVDVELALDE GGLLHARTSV TNTVAGDLHL SSVLTSLPVA AHATELLDLT GRWCKERTPQ
RHPWVQGTHR RDARHGRTGH DATLLLVAGT PGFSFGAGEA WAVHTAWSGN HTHYAERTPE
GDCLLGGGEL LAPGEVVLAT GETYRSPELL GSWSPAGLDP LSHRFHAHLR AITPRARTER
PVIANTWEAV YFDQSLERLA ELADVAASVG VERFVLDDGW FLGRRDDTTA LGDWTVDPDV
WPQGLGPLVE HVTGRGMQFG LWVEPEMVSP DSETARRHPE RVLRGRAAVP PAWRRQQVLD
LQDEAAYADL RDALLALLDE LDIAYLKWDH NRDLTDVTHD GRPAVHGQTL ATYTLLDELR
AAHPSLEIES CSSGGARVDA GVLARTDRVW ASDTNDPLER QHLQRWTSLL VPPELIGAHV
GPPTSHTTER THTLRYRAAT ALLHHFGIEW DMTGLDETAL GELASWIELH KRVRPLIGTG
TLVHPDHADP AVLVTGVVAA DRTEGWYVVA TVASTDTQHP AALRLTGLDP DRLYRLTEEL
PPGPGGADLT DSWSASGSTL TGRLLAVAGV ALPVLHPEEA RVLRVRAVDA
//
